The advanced oxidation technology of persulfate（PDS）activation by CuO have been hotly sought as one of the effective strategies for degrading organic pollutants in water. However, there are still certain issues such as the low efficiency of PDS activation, the small specific surface area of CuO, and the low conversion efficiency of Cu（II）/Cu（I）. Herein, the flake copper oxide（CCB-300）with high activity and large specific surface area（32.8m²/g）was successfully synthesized through a two-step hydrothermal-calcination method. Multiple characterization analysis, such as X-ray powder diffractometry（XRD）, N₂ adsorption-desorption analysis, Scanning electron microscopy（SEM）, Transmission electron microscopy（TEM）and X-ray photoelectron spectroscopy（XPS）, were utilized to analyze crystal structure, morphology and element composition of CCB-300. Furthermore, the performance of the CCB-300 for degradation of tetracycline（TC）via peroxydisulfate activation under visible light（Vis）was investigated. The findings revealed that the TC removal rate reached 96.9% within 60minutes under the circumstances of 0.05g/L CCB-300, 0.5mmol/L PDS, 50mg/L TC and unadjusted initial pH. Electron paramagnetic resonance spectroscopy（EPR）and radical quenching experiments indicated that both ¹O₂ produced by the non-radical pathways and and ⋅OH generated via the radical pathways were involved in the degradation reaction. Ultraviolet-visible diffuse reflectance spectroscopy and photoelectrochemical tests confirmed that CCB-300 exhibited excellent visible light absorption capacity and charge transfer performance. The photogenerated electrons excited by visible light accelerate the redox cycle of Cu（II）/Cu（I）, facilitating the conversion of PDS to and ⋅OH, and further enhancing the efficiency of TC degradation. The repeatable experiments demonstrated that CCB-300exhibited favorable reusability and stability. Finally, the possible reaction mechanism was proposed. This study provided a novel method for tetracycline degradation through synergistic persulfate activation by visible light and heterogeneous catalysts.