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Association between perfluoroalkyl and polyfluoroalkyl substances mixture exposure and hyperuricemia
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Yu FENG1, Shao-wei PU1, Zhu-mei CHEN1, Jun-liang ZHU1, Wei-jie CAI1, Hong-bo LIU1, 2, *
China Environmental Science | 2025, 45(1) : 322 - 330
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China Environmental Science | 2025, 45(1): 322-330
• Environmental Toxicology and Environmental Health •
Association between perfluoroalkyl and polyfluoroalkyl substances mixture exposure and hyperuricemia
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Yu FENG1, Shao-wei PU1, Zhu-mei CHEN1, Jun-liang ZHU1, Wei-jie CAI1, Hong-bo LIU1, 2, *
Affiliations
  • 1.Department of Health Statistics, School of Public Health, China Medical University, Shenyang 110122, China
  • 2.Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention, China Medical University, Shenyang 110122, China
Published: 2025-01-20
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To evaluate the association and combined effects of perfluoroalkyl and polyfluoroalkyl substances (PFAS) and mixtures on hyperuricemia (HUA) and identify key components, this study analyzed data from 2,564 subjects in the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2016 using logistic regression, weighted quantile sum regression, and Bayesian kernel machine regression. Higher levels of perfluorononanoic acid (PFNA), n-perfluorooctane sulfonic acid (n-PFOA), and perfluoromethylheptane sulfonic acid isomers (Sm-PFOS) were positively associated with HUA when PFAS was exposed as a single source (P<0.05). When considered as mixture exposure, PFAS mixtures were positively associated with HUA overall, with a 39.6% increase in the risk of HUA for each quartile increase in PFAS mixtures (WQS index) (OR=1.396,95%CI: 1.180~1.651, P<0.001), and this association was only observed in the female population. n-PFOA and Sm-PFOS were identified as key components, while linear perfluorooctane sulfonic acid (n-PFOS) and perfluorohexane sulfonic acid (PFHxS) may be negatively associated with HUA in the mixture. Potential interactions between various PFAS were also observed. The research findings can provide the latest epidemiological evidence for the study of the association between PFAS exposure and the risk of hyperuricemia, offering a basis for screening key populations.

hyperuricemia (HUA)  /  PFAS  /  mixtures  /  BKMR  /  WQS
Yu FENG, Shao-wei PU, Zhu-mei CHEN, Jun-liang ZHU, Wei-jie CAI, Hong-bo LIU. Association between perfluoroalkyl and polyfluoroalkyl substances mixture exposure and hyperuricemia[J]. China Environmental Science, 2025 , 45 (1) : 322 -330 .
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Year 2025 volume 45 Issue 1
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Article Info
  • Receive Date：2024-06-18
  • Online Date：2026-03-18
  • Published：2025-01-20
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  • Received：2024-06-18
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Affiliations
    1.Department of Health Statistics, School of Public Health, China Medical University, Shenyang 110122, China
    2.Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention, China Medical University, Shenyang 110122, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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