PDF
Full
Outline
In this research, BPS and BPF with sublethal dose were selected to compare the difference and combined toxicity of neurodevelopmental toxicity in zebrafish from four aspects: developmental phenotype, motor behavior, vascular development and neurotoxicity. The results showed that both BPS and BPF of LC5 induced apparent deformities in zebrafish, such as inhibiting the development of swimming sac and yolk sac. Exposure to BPS and BPF can affect the early motor behavior of zebrafish, which is potentially associated with damage to the cardiovascular system and nervous central system. BPS and BPF caused abnormal cardiovascular development and shortened caudal vein (CV) width in zebrafish. The abnormal transmission of DA, AChE and NO neurotransmitters leads to the impaired development of zebrafish neurons, which has a direct impact on the function of the lateral nervous system, and then leads to the impaired early motor behavior of zebrafish. BPS and BPF show different toxicity differences in specific indicators. BPF exposure is more likely to induce tissue and organ toxicity in zebrafish, while the direct toxicity of BPS is less than that of BPF, which is more manifested at the molecular level, indicating that there is a certain degree of difference in the mode of action of the two. In addition, combined with the analysis of the combined action of concentration addition model, the addition action between BPS and BPF is mainly. The results of this study provide a reference for health risk assessment and risk warning after exposure to BPS, BPF and their mixtures.
PDF
55
27
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
