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The development of the heart in zebrafish embryos was examined after exposure to different concentrations of thiabendazole (TBZ) solution (0.06, 0.6, and 6mg/L). The levels of catalase (CAT), superoxide dismutase (SOD), reactive oxygen species (ROS), and the expression of genes related to cardiac development were assessed. The results indicated that exposure to the high concentration of TBZ (6mg/L) caused severe cardiotoxicity, including pericardial edema and a reduced heart rate in zebrafish embryos. This concentration also induced significant oxidative stress in the heart, leading to a large number of apoptotic cells and marked changes in the expression of cardiac development-related genes (gate4, nppa, sox9b, vmhc), as well as apoptosis-related genes (bcl2, bax, puma, p53). These findings suggested that TBZ induced cardiotoxicity by disrupting the normal expression of genes involved in cardiac development, generating oxidative stress, and triggering apoptosis.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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