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Human lung cancer cell A549were used as the test cell. Three kinds of organophosphorus flame retardants, i.e., tris(2-butoxyethyl) phosphate (TBOEP), tris(1-chloro-2-propyl)phosphate (TCIPP), and tri(4-isopropylphenyl)phosphate (IPPP), were selected as representative compounds, which are frequently detected in the environment. The toxic effects of the three compounds on A549cell were studied through multiple toxicity test endpoints. Results showed that the three OPFRs could inhibit cell viability, stimulate the production of excessive reactive oxygen species and reduce the mitochondrial membrane potential in cell, induce cell inflammation and cause DNA damage. All the cytotoxicity indicators were dose-dependent. OPFRs with low concentrations had less effect, and the toxic effect enhanced with the increase of OPFRs concentrations. Compared with the three OPFRs, their toxic effects on A549cells ranked as TBOEP > TCIPP ≈ IPPP. Especially, when the cells were exposed to TBOEP with a high concentration of 500 μmol/L, the cell viability was less than 5%, the amount of reactive oxygen species in cell increased by three times, the mitochondrial membrane potential decreased by 46.5%, the secretion of inflammatory factors IL-6 and TNF-α increased by 124.4% and 262.7%, and the content of DNA damage markers increased significantly.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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