Full
Outline
To evaluate the vaccine effectiveness (VE) of the adsorbed acellular diphtheria-tetanus-pertussis (DTaP) vaccine in infants and young children aged 2 years and under in Gansu province, thereby providing evidence for optimizing the immunization strategies for pertussis in underdeveloped western regions of China.
A retrospective cohort was established, including 176 688 resident children born in Gansu province from January 1 to December 31, 2023. The Poisson regression model was adopted to calculate the relative risk (RR) for evaluating the VE of 1–4 doses of DTaP vaccine against pertussis and pertussis-related hospitalization, after adjusting for factors such as region and sex.
The coverage rates of the 1st to 4th doses of DTaP vaccine among infants and young children aged 2 years and under in Gansu province were 92.88%, 91.15%, 89.22%, and 41.96%, respectively. The VE of the 1st to 4th doses against pertussis was 43.67% (95%CI: 39.60%–55.21%), 71.30% (95%CI: 50.13%–79.96%), 90.91% (95%CI: 88.82%–92.68%), and 99.20% (95%CI: 77.91%–99.80%), respectively. The VE of the 1st to 4th doses against pertussis-related hospitalization was 56.14% (95%CI: 18.13%–77.80%), 63.90% (95%CI: 22.71%–85.46%), 73.02% (95%CI: 58.10%–82.34%), and 94.40% (95%CI: 64.32%–98.70%), respectively.
The DTaP vaccine provides significant protection against pertussis and pertussis-related hospitalization in infants and young children aged 2 years and under in Gansu province in a dose-dependent manner. Efforts should focus on improving the timeliness of primary immunization and the coverage of booster doses.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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