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Research progress in animal models of enterovirus-associated hand, foot, and mouth disease: a review
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Junjie MA1, 2, Yisheng SUN2
Chinese Journal of Public Health | 2026, 42(9) : 1140 - 1147
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Chinese Journal of Public Health | 2026, 42(9): 1140-1147
• Review •
Research progress in animal models of enterovirus-associated hand, foot, and mouth disease: a review
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Junjie MA1, 2, Yisheng SUN2
Affiliations
  • 1School of Public Health, Hangzhou Medical University, Hangzhou 310053, China
  • 2Zhejiang Key Lab of Vaccine, Infectious Disease Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310015, China
Published: 2026-09-10 doi: 10.11847/zgggws1149127
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Hand, foot, and mouth disease (HFMD) is a common infectious disease caused by enterovirus infections in children, and it is one of the major public health issues in China. Globally, only China has introduced monovalent inactivated vaccines against HFMD, and ideal animal models can accelerate the vaccine research and development. This article reviews recent research progress in animal models of enterovirus-associated HFMD after 2000. It discusses the advantages and limitations of each animal model and provides suggestions for the construction of animal models of enterovirus-associated HFMD, as well as the development of HFMD vaccines in China.

hand, foot, and mouth disease (HFMD)  /  enterovirus  /  animal model  /  vaccine research and development
马俊杰, 孙一晟. 手足口病相关肠道病毒感染动物模型研究进展. 中国公共卫生, 2026 , 42 (9) : 1140 -1147 . DOI: 10.11847/zgggws1149127
Junjie MA, Yisheng SUN. Research progress in animal models of enterovirus-associated hand, foot, and mouth disease: a review[J]. Chinese Journal of Public Health, 2026 , 42 (9) : 1140 -1147 . DOI: 10.11847/zgggws1149127
Year 2026 volume 42 Issue 9
139
53
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Article Info
doi: 10.11847/zgggws1149127
  • Receive Date:2025-10-20
  • Online Date:2026-10-23
  • Published:2026-09-10
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History
  • Received:2025-10-20
  • Revised:2026-02-24
  • Accepted:2026-04-04
Affiliations
    1School of Public Health, Hangzhou Medical University, Hangzhou 310053, China
    2Zhejiang Key Lab of Vaccine, Infectious Disease Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310015, China

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SUN Yisheng, E-mail:
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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