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Associations between triglyceride glucose-obesity composite indices and risk of hyperuricemia among adults in Qingdao, China: a prospective cohort study
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Haojia WU1, Jian SUN2, Meiyi YE3, Zhi WANG4, Baozhu GUO1, Jing CUI4, Jianping SUN4
Chinese Journal of Public Health | 2025, 41(10) : 1168 - 1175
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Chinese Journal of Public Health | 2025, 41(10): 1168-1175
• Epidemiological Research •
Associations between triglyceride glucose-obesity composite indices and risk of hyperuricemia among adults in Qingdao, China: a prospective cohort study
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Haojia WU1, Jian SUN2, Meiyi YE3, Zhi WANG4, Baozhu GUO1, Jing CUI4, Jianping SUN4
Affiliations
  • 1School of Public Health, Shandong Second Medical University, Weifang 261053, China
  • 2Department of Urology, Qingdao Women and Children’s Hospital, Qingdao 266000, China
  • 3College of Humanities and Social Sciences, Dalian Medical University, Dalian 116000, China
  • 4Qingdao Center for Disease Control and Prevention/Qingdao Institute of Preventive Medicine, Qingdao 266000, China
Published: 2025-10-10 doi: 10.11847/zgggws1146826
Outline
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Objective

To explore the associations between triglyceride glucose (TyG)-obesity composite indices and the risk of hyperuricemia (HUA) in Qingdao, China, providing a basis for the prevention and management of HUA.

Methods

A prospective cohort study was conducted, encompassing a total of 3 294 adults recruited in the baseline survey from 2006 to 2009 and participating the follow-up survey from 2012 to 2015 and 2019 to 2023. Cox proportional hazards regression was adopted to analyze the associations of baseline TyG-body mass index (TyG-BMI) and TyG-waist circumference (TyG-WC) with the risk of HUA. The restricted cubic spline method was used to analyze the dose-response relationships of baseline TyG-BMI and TyG-WC with the risk of HUA. Subgroup analyses were performed based on covariates such as gender and age, and their interactions with the TyG-obesity composite indices were analyzed.

Results

A total of 430 (13.1%) adults were identified with HUA. Multivariate Cox regression analysis showed that the highest quartiles of baseline TyG-BMI and TyG-WC increased the risk of HUA by 48% (HR = 1.48, 95%CI: 1.10–1.99) and 46% (HR = 1.46, 95%CI: 1.08–1.99) compared with the lowest quartiles. Restricted cubic splines indicated linear dose-response relationships of baseline TyG-BMI (Poverall < 0.001, Pnon-linear = 0.639) and TyG-WC (Poverall < 0.001, Pnon-linear = 0.776) with the risk of HUA. Subgroup analyses showed that the highest quartiles of baseline TyG-obesity composite indices in females, rural adults, and hypertension adults were higher than those in males, urban adults, and non-hypertension adults (all P < 0.05). No significant interactions were observed with TyG-obesity composite indices (all P > 0.05).

Conclusion

Elevated baseline levels of TyG-BMI and TyG-WC are associated with an increased risk of HUA, particularly among females, rural adults, and hypertension adults.

hyperuricemia (HUA)  /  triglyceride glucose (TyG) index  /  obesity  /  metabolic syndrome  /  prospective cohort study  /  adult  /  Qingdao city
吴浩佳, 孙健, 叶美怡, 王治, 郭宝柱, 崔静, 孙健平. 青岛市成年人TyG–肥胖联合指数与高尿酸血症发病关系的前瞻性队列研究. 中国公共卫生, 2025 , 41 (10) : 1168 -1175 . DOI: 10.11847/zgggws1146826
Haojia WU, Jian SUN, Meiyi YE, Zhi WANG, Baozhu GUO, Jing CUI, Jianping SUN. Associations between triglyceride glucose-obesity composite indices and risk of hyperuricemia among adults in Qingdao, China: a prospective cohort study[J]. Chinese Journal of Public Health, 2025 , 41 (10) : 1168 -1175 . DOI: 10.11847/zgggws1146826
Appendix
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Year 2025 volume 41 Issue 10
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Article Info
doi: 10.11847/zgggws1146826
  • Receive Date：2024-12-31
  • Online Date：2026-10-25
  • Published：2025-10-10
Article Data
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History
  • Received：2024-12-31
  • Revised：2025-07-12
  • Accepted：2025-08-02
Affiliations
    1School of Public Health, Shandong Second Medical University, Weifang 261053, China
    2Department of Urology, Qingdao Women and Children’s Hospital, Qingdao 266000, China
    3College of Humanities and Social Sciences, Dalian Medical University, Dalian 116000, China
    4Qingdao Center for Disease Control and Prevention/Qingdao Institute of Preventive Medicine, Qingdao 266000, China

Corresponding:

SUN Jianping, E-mail:
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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