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Outline
As an emerging disinfection technology, 222-nm ultraviolet C light (222-nm UVC) has attracted considerable research interest due to its potent broad-spectrum antimicrobial properties and potentially favorable biosafety profile. This review provides a systematic examination of the photochemical mechanisms mediating the germicidal effects of 222-nm UVC and comprehensively evaluates the biosafety of this technology, with a particular emphasis on potential impacts on cutaneous barrier integrity and ocular surface tissue. Furthermore, we discuss the risk of ozone generation during 222-nm UVC application and critically analyze recent advances in disinfection protocols and device development. By synthesizing current evidence, this review aims to establish a scientific foundation for the precise clinical implementation of this technology and optimize the balance between antimicrobial efficacy and human safety to facilitate the translational applications of this technology in healthcare-associated infection control and public health emergency management.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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