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Dengue epidemic characteristics and vaccine research progress: a review
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Jun LIU1, Yanju QIN2, Jiayun DING1, Ruiting TANG2, Qing XIE1, Jian KUANG1, Zhijian ZHOU1
Chinese Journal of Public Health | 2025, 41(4) : 500 - 504
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Chinese Journal of Public Health | 2025, 41(4): 500-504
• Review •
Dengue epidemic characteristics and vaccine research progress: a review
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Jun LIU1, Yanju QIN2, Jiayun DING1, Ruiting TANG2, Qing XIE1, Jian KUANG1, Zhijian ZHOU1
Affiliations
  • 1Department of Biosafety, Center for Disease Prevention and Control of the Southern Theatre Command of the PLA, Guangzhou 510507, China
  • 2School of Public Health, Guangzhou Medical University, Guangzhou 510000, China
Published: 2025-04-10 doi: 10.11847/zgggws1146153
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Dengue fever is a mosquito-borne viral infectious disease transmitted by Aedes mosquitoes carrying the dengue virus (DENV). It is currently prevalent in over 100 tropical and subtropical countries and regions, and was listed by the WHO as one of the "Top Ten Global Health Threats" in 2019. DENV has four serotypes, all of which can cause dengue fever. Secondary infection with a different serotype often leads to more severe clinical symptoms, making dengue vaccine development challenging. Currently, there are no specific drugs for the treatment of dengue fever, and vaccine development remains the preferred strategic approach for prevention and control. This review summarizes the basic characteristics, epidemiological features, infection and immune responses, and current status of dengue vaccine development, and analyzes the challenges faced in dengue vaccine development, providing a reference for future dengue prevention and control and related research.

dengue fever  /  vaccine  /  epidemic characteristics  /  immune response
刘军, 覃燕菊, 丁家云, 唐瑞婷, 谢晴, 匡健, 周志坚. 登革热流行特征及疫苗研究进展. 中国公共卫生, 2025 , 41 (4) : 500 -504 . DOI: 10.11847/zgggws1146153
Jun LIU, Yanju QIN, Jiayun DING, Ruiting TANG, Qing XIE, Jian KUANG, Zhijian ZHOU. Dengue epidemic characteristics and vaccine research progress: a review[J]. Chinese Journal of Public Health, 2025 , 41 (4) : 500 -504 . DOI: 10.11847/zgggws1146153
Year 2025 volume 41 Issue 4
89
36
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Article Info
doi: 10.11847/zgggws1146153
  • Receive Date:2024-10-27
  • Online Date:2026-10-25
  • Published:2025-04-10
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History
  • Received:2024-10-27
  • Revised:2024-12-06
  • Accepted:2025-02-17
Affiliations
    1Department of Biosafety, Center for Disease Prevention and Control of the Southern Theatre Command of the PLA, Guangzhou 510507, China
    2School of Public Health, Guangzhou Medical University, Guangzhou 510000, China

Corresponding:

ZHOU Zhijian, E-mail:
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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