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Analysis of the disease burden of hand, foot, and mouth disease in Guangdong province from 2015 to 2023: based on surveillance data
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Hui ZHANG1, 2, 3, Jienan ZHENG1, 2, 3, Danxia LUO1, 2, 3, Biao ZENG4, Yao YI4, Fen YANG4, Liling LIN4, Min KANG4, Aiping DENG4, Yingtao ZHANG4
Chinese Journal of Public Health | 2026, 42(3) : 319 - 324
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Chinese Journal of Public Health | 2026, 42(3): 319-324
• Survey and Report •
Analysis of the disease burden of hand, foot, and mouth disease in Guangdong province from 2015 to 2023: based on surveillance data
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Hui ZHANG1, 2, 3, Jienan ZHENG1, 2, 3, Danxia LUO1, 2, 3, Biao ZENG4, Yao YI4, Fen YANG4, Liling LIN4, Min KANG4, Aiping DENG4, Yingtao ZHANG4
Affiliations
  • 1School of Pharmaceutical Business, Guangdong Pharmaceutical University, Guangzhou 510006, China
  • 2Guangdong Health Economics and Health Promotion Research Center, Guangzhou 510006, China
  • 3Guangdong Health Economics and One Health Research Center, Guangzhou 510006, China
  • 4Institute for Infectious Disease Control and Prevention, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China
Published: 2026-03-10 doi: 10.11847/zgggws1145847
Outline
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Objective

To estimate the socio-economic burden caused by various types of hand-foot-mouth disease (HFMD) cases in Guangdong province from 2015 to 2023.

Methods

On the basis of the previous studies of disease economic burden and the data of HFMD reported in Guangdong from 2015 to 2023, the economic burdens of common cases (including outpatients and inpatients), severe cases, and death cases of HFMD were estimated. The per capita productivity loss caused by premature death of HFMD in different age groups was calculated by the human capital method.

Results

From 2015 to 2023, a total of 2 727 381 cases of HFMD were reported in Guangdong province, with 99.96% classified as common cases, 932 severe cases, and 33 death cases. The annual economic loss attributable to HFMD in Guangdong province during this period remained stable at 357 million–523 million CNY, except for a notable decrease between 2020 and 2022, when it was estimated at 76 million–370 million CNY. The economic burden of common cases accounted for 99.38%. The economic burden of severe cases accounted for 0.59%, showing a fluctuating downward trend from 5 million CNY in 2015 to 0.756 3 million CNY in 2023. The economic burden associated with death cases accounted for 1.03%, exhibiting a declining trend from 6 million CNY in 2015 to no death in 2022–2023, with premature death losses constituting 98.41%–98.66% of total death losses.

Conclusions

The socio-economic burden caused by HFMD in Guangdong province has been generally stable from 2015 to 2023, apart from a decline in 2020–2022. The burden was mainly attributable to common cases, and the disease burden of severe and death cases decreased with fluctuations. It is recommended that we should closely monitor changes in the composition of the economic burden of HFMD and adjust prevention and control strategies accordingly.

hand-foot-mouth disease  /  disease burden  /  premature death loss  /  Guangdong province
张慧, 郑洁楠, 罗丹霞, 曾彪, 易瑶, 杨芬, 林丽玲, 康敏, 邓爱萍, 张应涛. 2015—2023年广东省手足口病疾病负担分析:基于监测资料. 中国公共卫生, 2026 , 42 (3) : 319 -324 . DOI: 10.11847/zgggws1145847
Hui ZHANG, Jienan ZHENG, Danxia LUO, Biao ZENG, Yao YI, Fen YANG, Liling LIN, Min KANG, Aiping DENG, Yingtao ZHANG. Analysis of the disease burden of hand, foot, and mouth disease in Guangdong province from 2015 to 2023: based on surveillance data[J]. Chinese Journal of Public Health, 2026 , 42 (3) : 319 -324 . DOI: 10.11847/zgggws1145847
Year 2026 volume 42 Issue 3
101
40
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Article Info
doi: 10.11847/zgggws1145847
  • Receive Date:2024-09-03
  • Online Date:2026-10-23
  • Published:2026-03-10
Article Data
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History
  • Received:2024-09-03
  • Revised:2025-01-06
  • Accepted:2025-08-28
Affiliations
    1School of Pharmaceutical Business, Guangdong Pharmaceutical University, Guangzhou 510006, China
    2Guangdong Health Economics and Health Promotion Research Center, Guangzhou 510006, China
    3Guangdong Health Economics and One Health Research Center, Guangzhou 510006, China
    4Institute for Infectious Disease Control and Prevention, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China

Corresponding:

ZHANG Yingtao, E-mail:
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表12种不同金属材料的力学参数
科
Family
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Number of
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Number of
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Number of
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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