Full
Outline
To investigate the positive rate of hepatitis E virus (HEV) immunoglobulin G (IgG) antibodies in pregnant women in China and to provide a reference for the prevention and control of hepatitis E in the women.
PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang Data were searched, supplemented by a retrospective literature search, to collect relevant literature published domestically and internationally from January 1, 1989, to December 31, 2023, on the seroprevalence of HEV in pregnant women in China. R 3.5.2 software was used for meta-analysis of the included literature.
A total of 15 articles (8 in Chinese and 7 in English) were included, with a cumulative study population of 36 188. The meta-analysis showed that the positive rate of HEV IgG antibodies among pregnant women in China was 13% (95% confidence interval [95%CI]: 11%–16%). Subgroup analysis showed that the positive rates of HEV IgG antibodies in pregnant women younger than 30 years old and 30 years old and older were 18% (95%CI: 12%–24%) and 15% (95%CI: 10%–19%), respectively; the positive rates of HEV IgG antibodies in pregnant women living in urban and rural areas were 29% (95%CI: 3%–55%) and 25% (95%CI: 5%–45%), respectively; and the positive rates of HEV IgG antibodies in pregnant women in the first, second, and third trimesters were 16% (95%CI: 3%–28%), 13% (95%CI: 7%–18%), and 15% (95%CI: 10%–21%), respectively. There were no statistically significant differences in the positive rates of HEV IgG antibodies among pregnant women of different ages, residences, and gestational ages (all P>0.05). Sensitivity analysis and publication bias tests showed that there was no publication bias in the literature included in this meta-analysis, and the results were relatively stable.
The positive rate of HEV IgG antibodies among pregnant women in China is relatively high. Attention should be paid to this high-risk group, and prevention and control measures for HEV infection should be strengthened.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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