Full
Outline
To differentiate between "indeterminate" early and late HIV infection samples to ensure timely follow-up.
A retrospective analysis was conducted on all "indeterminate" HIV infection samples from the Pudong New Area confirmatory laboratory between 2014 and 2019. Samples were grouped based on epidemiological data and follow-up results: 58 "early positive-indeterminate"and 31 "late positive-indeterminate"samples. Fourth-generation rapid diagnostic tests (RDTs) and third-generation enzyme-linked immunosorbent assays (ELISAs) were performed on both groups. The characteristics of the screening results and confirmatory bands were analyzed, and the differences in CD4+T cell levels before and after 3 years of treatment were compared between the two groups.
Both the fourth-generation RDT and third-generation ELISA antibody tests were 100% positive in both the "early positive-indeterminate" and "late positive-indeterminate" groups. However, the S/CO values from the third-generation ELISA showed a statistically significant difference between the two groups (t=31.65, P<0.001). The proportions of different band patterns in the antibody confirmatory test that transitioned to "early positive" and "late positive" were also statistically significant (χ2=65.10, P<0.001). The overall distribution of changes in CD4+T cell counts before and after 3 years of treatment differed significantly between the "early positive-indeterminate" and "late positive-indeterminate"groups (U=415.5, P<0.001).
Combining screening results and confirmatory band characteristics can effectively distinguish different stages of infection in "indeterminate" HIV antibody results and provide corresponding follow-up recommendations. Furthermore, changes in CD4+T cell counts before and after treatment can be used to assess immune reconstitution following treatment.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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