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Research progress on the mechanism of exercise in improving the comorbidity of inflammatory pain and depression
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Xiaoxue ZHANG1, Hongru LI2, Meidan ZHAO1, Xiao HAN1, Jian ZHANG1, *, Tianyi ZHAO3, *
Chinese Journal of Comparative Medicine | 2026, 36(6) : 114 - 121
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Chinese Journal of Comparative Medicine | 2026, 36(6): 114-121
• Research Progress •
Research progress on the mechanism of exercise in improving the comorbidity of inflammatory pain and depression
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Xiaoxue ZHANG1, Hongru LI2, Meidan ZHAO1, Xiao HAN1, Jian ZHANG1, *, Tianyi ZHAO3, *
Affiliations
  • 1.School of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
  • 2.Experimental Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617
  • 3.School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617
Published: 2026-03-30 doi: 10.3969/j.issn.1671-7856.2026.06.011
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Inflammatory pain and depression are clinically common disorders with a high comorbidity rate. They mutually exacerbate their pathological processes and severely reduce the quality of life of patients. The pathogenesis of the comorbidity of inflammatory pain and depression is highly complex, posing significant challenges for clinical diagnosis and treatment. Recent studies have revealed that sustained activation of neuroinflammation is a central pathological link in the comorbidity of inflammatory pain and depression. As a non-pharmacological intervention, exercise can effectively improve both pain and depressive symptoms in patients with comorbidity. However, its specific mechanisms of action remain incompletely elucidated. This article summarizes recent research advances on the effects of exercise in inhibiting central inflammation, modulating the balance of microglial M1/M2 polarization, regulating neuronal excitatory-inhibitory homeostasis, and promoting hippocampal neurogenesis. It systematically reviews the molecular and neural mechanisms by which exercise modulates neuroinflammation to treat the comorbidity of inflammatory pain and depression, with the aim of providing a theoretical basis and practical guidance for clinical exercise therapy.

exercise  /  inflammatory pain  /  depression  /  neuroinflammation
Xiaoxue ZHANG, Hongru LI, Meidan ZHAO, Xiao HAN, Jian ZHANG, Tianyi ZHAO. Research progress on the mechanism of exercise in improving the comorbidity of inflammatory pain and depression[J]. Chinese Journal of Comparative Medicine, 2026 , 36 (6) : 114 -121 . DOI: 10.3969/j.issn.1671-7856.2026.06.011
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Year 2026 volume 36 Issue 6
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Article Info
doi: 10.3969/j.issn.1671-7856.2026.06.011
  • Receive Date：2025-08-26
  • Online Date：2026-08-05
  • Published：2026-03-30
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  • Received：2025-08-26
Funding
Affiliations
    1.School of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
    2.Experimental Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617
    3.School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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