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Outline
Using a molecular hybridization strategy, 17 peptidomimetic derivatives of phenylalanine were designed and synthesized by combining an aminothiazole oxime scaffold with phenylalanine for antibacterial activity studies. The results showed that these compounds exhibited varying degrees of inhibitory activity against the tested bacterial strains, with compound 8p being particularly outstanding. It demonstrated minimal inhibitory concentrations (MIC) of 2 μg·mL-1 against E. coli, P. aeruginosa, and fluoroquinolone-resistant E. coli (FREC). Its activity against E. coli and P. aeruginosa was comparable to that of the reference drug ciprofloxacin, while its efficacy against FREC was significantly superior to the reference drug. Meanwhile, compound 8p exhibited synergistic effects when combined with certain antibacterial agents. Its relatively significant antibacterial activities and synergistic enhancement warrant further investigation.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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