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siRNA therapy for metabolic dysfunction-associated steatotic liver disease
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Yu-xiao LIU, Xing-feng LIU, Wen-jia FAN, Ping-ping LI*
Acta Pharmaceutica Sinica | 2026, 61(9) : 3302 - 3315
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Acta Pharmaceutica Sinica | 2026, 61(9): 3302-3315
• Reviews •
siRNA therapy for metabolic dysfunction-associated steatotic liver disease
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Yu-xiao LIU, Xing-feng LIU, Wen-jia FAN, Ping-ping LI*
Affiliations
  • State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
Published: 2026-09-12 doi: 10.16438/j.0513-4870.2026-0264
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Metabolic dysfunction-associated steatotic liver disease (MASLD) is currently the most prevalent chronic liver disease worldwide. Its pathogenesis involves the interplay of lipid dysregulation, insulin resistance, oxidative stress, inflammation, gut microbiota dysbiosis, and genetic susceptibility variants. Current therapeutic interventions primarily rely on systemic administration, with their hepatic specificity or selectivity remaining to be improved. Small interfering RNA (siRNA) therapy offers a novel strategy by precisely silencing hepatic pathogenic genes to block aberrant protein synthesis. This review outlines the mechanisms of action and the delivery systems of siRNA therapeutics. Focusing on the core pathological drivers of MASLD, it details the clinical progress and mechanistic insights of siRNA therapeutics within three main areas: Genetic risk variants, lipid metabolism regulation, and fibrosis-inflammation pathways. This article provides an updated reference for siRNA drug development in MASLD.

metabolic dysfunction-associated steatotic liver disease  /  liver targeting  /  small interfering RNA  /  gene silencing  /  delivery system
刘玉骁, 柳星峰, 范雯嘉, 李平平. 代谢功能障碍相关脂肪性肝病的小干扰RNA治疗. 药学学报, 2026 , 61 (9) : 3302 -3315 . DOI: 10.16438/j.0513-4870.2026-0264
Yu-xiao LIU, Xing-feng LIU, Wen-jia FAN, Ping-ping LI. siRNA therapy for metabolic dysfunction-associated steatotic liver disease[J]. Acta Pharmaceutica Sinica, 2026 , 61 (9) : 3302 -3315 . DOI: 10.16438/j.0513-4870.2026-0264
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Year 2026 volume 61 Issue 9
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doi: 10.16438/j.0513-4870.2026-0264
  • Receive Date：2026-03-11
  • Online Date：2026-10-22
  • Published：2026-09-12
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  • Received：2026-03-11
  • Revised：2026-04-14
Affiliations
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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