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A sesquiterpenoid with an unprecedented 7,8-seco-guaiane skeleton from Stellera chamaejasme L.
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You-min YING1, Ji-geng CAO1, Ting TIAN1, Jing TANG1, Shi-lei WANG2, *, Wei-guang SHAN1, *
Acta Pharmaceutica Sinica | 2026, 61(8) : 3123 - 3128
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Acta Pharmaceutica Sinica | 2026, 61(8): 3123-3128
• Original Articles •
A sesquiterpenoid with an unprecedented 7,8-seco-guaiane skeleton from Stellera chamaejasme L.
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You-min YING1, Ji-geng CAO1, Ting TIAN1, Jing TANG1, Shi-lei WANG2, *, Wei-guang SHAN1, *
Affiliations
  • 1College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China
  • 2College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China
Published: 2026-08-12 doi: 10.16438/j.0513-4870.2026-0364
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The chemical constituents of Stellera chamaejasme L. were separated by comprehensive column chromatography on MCI, ODS C-18, Toyopearl HW-40C, and silica gels. Structures of the isolated compounds were determined by NMR (nuclear magnetic resonance), MS (mass spectrometry), IR (infrared spectroscopy), and quantum chemical calculations. Nine compounds were isolated from the chloroform fraction 95% ethanol extract of the titled plant and identified as chamaejaslactone A (1), stelleranoid A (2), stelleranoid D (3), stelleranoid E (4), wikstronone A (5), wikstronone C (6), chamaejasmone D (7), daphnauranol A (8), and holosericin B (9), respectively. Among them, compound 1 was characterized as the first example of a sesquiterpenoid with an unprecedented 7,8-seco-guaiane skeleton. In the in vitro bioassay, compound 1 exhibited moderate inhibitory activity against Escherichia coli-originated β-glucuronidase with an IC50 value of 51.79 ± 3.21 μmol·L-1.

Thymelaeaceae  /  Stellera chamaejasme  /  sesquiterpenoid  /  guaiane  /  β-glucuronidase
应优敏, 曹季庚, 田婷, 唐静, 王石磊, 单伟光. 瑞香狼毒中一个具有新颖7,8-裂环愈创木烷骨架的倍半萜. 药学学报, 2026 , 61 (8) : 3123 -3128 . DOI: 10.16438/j.0513-4870.2026-0364
You-min YING, Ji-geng CAO, Ting TIAN, Jing TANG, Shi-lei WANG, Wei-guang SHAN. A sesquiterpenoid with an unprecedented 7,8-seco-guaiane skeleton from Stellera chamaejasme L.[J]. Acta Pharmaceutica Sinica, 2026 , 61 (8) : 3123 -3128 . DOI: 10.16438/j.0513-4870.2026-0364
Appendix
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Year 2026 volume 61 Issue 8
237
113
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Article Info
doi: 10.16438/j.0513-4870.2026-0364
  • Receive Date：2026-04-01
  • Online Date：2026-09-21
  • Published：2026-08-12
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History
  • Received：2026-04-01
  • Revised：2026-05-14
Affiliations
    1College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China
    2College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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