Full
Outline
Tumor necrosis factor receptor-associated factor 2 (TRAF2) is a central signaling adaptor that integrates multiple oncogenic pathways and represents potential target for cancer therapy. In this study, leveraging the extensive protein-protein interaction network of TRAF2, 100 "undruggable" key tumor-associated proteins were selected to screen for TRAF2 interactors. It was found that cytokine receptor-like factor 2 (CRLF2) is a novel interacting protein of TRAF2, and the liquidambaric acid (LDA), which can directly target TRAF2, can inhibit the TRAF2/CRLF2 interaction. Binding site studies revealed that CRLF2 binds to the TRAF domain of TRAF2 and can be blocked by LDA. Functional studies of CRLF2 indicated that TRAF2 is a key protein in the CRLF2-STAT3 (signal transducer and activator of transcription 3) signaling pathway, and LDA can regulate CRLF2-related STAT3 phosphorylation. In summary, this study reveals the TRAF2-mediated tumor protein interaction network and elucidates a new mechanism by which LDA exerts antitumor effects by inhibiting TRAF2/CRLF2 interaction to regulate the STAT3 signaling pathway. It also provides new theoretical guidance and potential strategies for the development of anti-tumor drugs targeting undruggable targets.
280
132
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
