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In recent years, conjugated drugs have become a hotspot in drug research and development due to their precise target binding. Radionuclide drug conjugates (RDC) are an emerging class of targeted conjugated drugs that combine diagnostic and therapeutic functions, representing a new drug type with immense development potential. Due to structural differences, RDC drugs exhibit distinct in vivo processes — absorption, distribution, metabolism, excretion, and toxicity (ADMET) — as well as unique bioanalytical methods compared to small molecule drugs. Starting from the analysis of the physicochemical properties of RDC, this article analyzed the pharmacokinetic characteristics and its application in the PK model selection of RDC and summarized the bioanalysis methods of such drugs, aiming to promote further development of RDC.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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