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Two compounds were isolated from the traditional Chinese medicine Ganoderma lucidum using various chromatographic techniques. Through methods such as one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy, both compounds were identified as new lanostane-type triterpenoids. Their absolute configurations were determined via quantum chemical calculations, and they were named baoslingzhines X and Y (1 and 2). In vitro and in vivo experimental results revealed that these two compounds exhibit potent activity against neuroinflammation, oxidative stress, and depression. All animal experiments were approved by the Institutional Animal Care and Use Committee (IACUC) of Shenzhen University (approval number: IACUC-202400148).
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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