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Outline
Chemotherapy-induced immune-priming cell death (ICD) is a unique form of cell death. By inducing this type of cell death through specific methods, cells can express damage-associated molecular patterns (DAMPs). These DAMPs can act as antigens to activate the host's immune system, thereby enhancing antitumor immune responses. Its clinical application has also attracted widespread attention. This review summarizes the molecular mechanisms of ICD, including pathways such as endoplasmic reticulum stress, autophagy, and necroptosis, as well as the mechanisms by which various chemotherapeutic drugs induce ICD. Additionally, this review explores the application of ICD in clinical practice, discusses its potential to provide new ideas and challenges for cancer treatment by categorizing it according to different types of cancer, and examines the possibility of applying ICD mechanisms in other diseases.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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