Full
Outline
Rheumatoid arthritis (RA), a chronic autoimmune disease, causes progressive cartilage destruction and bone erosion, and also affects vital organs. It affects approximately 0.5%-1% of the global population. Its treatment faces challenges such as insufficient drug targeting, significant systemic side effects and low patient compliance. Responsive microneedle technology integrates inflammatory microenvironment-sensitive materials with intelligent delivery technology to construct a microneedle delivery system that can sense site-specific markers of inflammation (e.g., pH, enzyme activity, or oxidative stress level) to achieve precise local delivery of anti-RA drugs in synovial tissues. Compared with systemic drug delivery, this technology significantly improves local drug concentration in the joints, effectively avoiding the risk of myelosuppression and liver and kidney toxicity associated with traditional therapies. The intelligent response characteristics of microneedles can dynamically regulate the release rate of the drug, so that the drug can be released on demand. The microneedle patch design can significantly reduce the frequency of drug delivery, which significantly improves the long-term treatment adherence. This review systematically explains the classification of responsive microneedles in terms of mechanism of action, material innovation and therapeutic advantages, analyses the current translational bottlenecks, and explores the prospects for their development in the individualized treatment of RA.
276
130
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
