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This study preliminarily explored the application of gastrodin (GAS) as a brain-targeting ligand for the construction of a novel glucose transporter (glucose transporter type 1, GLUT1) mediated brain-targeted lipid drug delivery system, aiming to achieve cascade-enhanced effects across the blood brain barrier and subsequent tumor targeting. Gastrodin-modified liposomes were successfully prepared using the thin-film hydration method, and their physicochemical properties, drug release characteristics, as well as in vitro and in vivo targeting abilities were preliminarily evaluated. Particular attention was paid to the in vitro and in vivo performance of gastrodin-modified liposomes prepared via a tri-branched conjugation strategy (GAS3-Lip). The gastrodin-modified liposomes exhibited favorable targeting to bEnd.3 brain microvascular endothelial cells and GL261 glioma cells, as well as significant accumulation at the lesion site in vivo. In both in vitro and in vivo pharmacodynamic evaluations, the tri-branched gastrodin-modified doxorubicin-loaded liposomes (GAS3-Lip/DOX) demonstrated stronger inhibitory effects against glioma compared with the classic glutathione (glutathione, GSH) modified brain-targeting liposomes, and the relevant animal experiments were approved by the Animal Experiment Ethics Committee of Southern Medical University (No: SMUL202412013). In conclusion, this strategy may provide a valuable approach for drug delivery research targeting glioma therapy.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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