Thirteen compounds were isolated from the twigs and leaves of Meiogyne hainanensis (Merr.) N. T. Ban by silica gel column chromatography, sephadex LH-20, and preparative HPLC. Their structures were respectively determined as chienhainanin N (1), (S)-15, 16-didehydrocoriolic acid methyl ester (2), 13-hydroxy-9Z, 11E, 15E-octadecatrienoic acid (3), (S)-coriolic acid (4), 13-oxo-(9Z, 11E)-octadecadienic acid (5), 13-oxo-(9E, 11E)-octadecadienic acid (6), 9-oxo-(10E, 12Z)-octadecadienic acid (7), 9-oxo-(10E, 12E)-octadecadienic acid (8), α-tocopherol (9), vitamin E quinone (10), α-tocospiro A (11), 17c-ethoxypheaophorbide A (12), mustakone (13) by spectral data analysis. Among them, compound 1 is a new compound, compounds 2, 3, 5-8, 10-12 are isolated from Annonaceae plants for the first time, and compounds 4, 9 and 13 are isolated from the genus Meiogyne for the first time. Their antimicrobial activities were evaluated by the broth microdilution method. Compounds 2, 3, 5-7 showed weak antimicrobial effect against MRSA with MIC values from 64 to128 μg·mL-1, respectively. Compound 13 showed weak antimicrobial effects against Cryptococcus neoformans with the MIC value of 128 μg·mL-1.
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |