Full
Outline
Tumor-associated macrophages (TAMs) have a dual role in the tumor microenvironment, mediating both immune activation and suppression. M1-TAMs kill tumor cells, while M2-TAMs are immunosuppressive and promote tumor growth. The activation of TAMs and enhancement of their anti-tumor immune function is a major goal in cancer immunotherapy. Here, we report a novel pyrazole derivative, IHMT-140, which reprograms tumor-promoting M2 macrophages into tumor-suppressing M1 macrophages, thereby inhibiting tumor growth. Mechanistically, IHMT-140 raises lysosomal pH in M2 macrophages, blocking autophagy and activating MAPK and NF-κB signaling, which induces M2-TAMs to M1-TAMs and mediates the anti-tumor response. As a potential immunomodulator, IHMT-140 provides not only a new tool for studying TAM reprogramming, but also a foundation for developing related immunotherapies. All animal experimental protocols were approved by the Hefei Institutes of Physical Science, Chinese Academy of Sciences, with approval number DWLL-2023-116.
222
103
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
