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The direct target and synergistic action of sulbactam against Acinetobacter baumannii
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Xin-yi LI, Qiong-lu DUAN, Xi ZHU, Ya-nan NI, Dan-qing SONG, Ying-hong LI*
Acta Pharmaceutica Sinica | 2026, 61(4) : 1276 - 1282
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Acta Pharmaceutica Sinica | 2026, 61(4): 1276-1282
• Original Articles •
The direct target and synergistic action of sulbactam against Acinetobacter baumannii
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Xin-yi LI, Qiong-lu DUAN, Xi ZHU, Ya-nan NI, Dan-qing SONG, Ying-hong LI*
Affiliations
  • Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2026-04-12 doi: 10.16438/j.0513-4870.2025-1108
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β-Lactamase inhibitor sulbactam has unique activity against Acinetobacter baumannii, but its direct target protein has not been fully elucidated. In this research, thermal proteome profiling and surface plasmon resonance technologies were applied to identify and validate RNA 5′ pyrophosphohydrolase (RppH) as the direct target of sulbactam against A. baumannii. And further, using the checkerboard method, we found that sulbactam could synergize with carbapenem antibiotics to battle A. baumannii. The research results supplement the new molecular mechanism of action of sulbactam and provide an effective combined regimen for its combination with other antibiotics to combat clinical intractable drug-resistant bacteria infections.

A. baumannii  /  sulbactam  /  thermal proteome profiling  /  RNA 5′ pyrophosphohydrolase  /  checkerboard method
李欣怡, 段琼璐, 朱喜, 倪亚楠, 宋丹青, 李迎红. 舒巴坦抗鲍曼不动杆菌直接靶点及协同增敏抗生素的研究. 药学学报, 2026 , 61 (4) : 1276 -1282 . DOI: 10.16438/j.0513-4870.2025-1108
Xin-yi LI, Qiong-lu DUAN, Xi ZHU, Ya-nan NI, Dan-qing SONG, Ying-hong LI. The direct target and synergistic action of sulbactam against Acinetobacter baumannii[J]. Acta Pharmaceutica Sinica, 2026 , 61 (4) : 1276 -1282 . DOI: 10.16438/j.0513-4870.2025-1108
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Year 2026 volume 61 Issue 4
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doi: 10.16438/j.0513-4870.2025-1108
  • Receive Date：2025-09-18
  • Online Date：2026-09-21
  • Published：2026-04-12
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  • Received：2025-09-18
  • Revised：2025-10-13
Affiliations
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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