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Okeanopeptin A, a new anabaenopeptin from marine cyanobacterium Okeanomitos corallinicola
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Hua-qing HUANG1, 2, Li-fen LIANG1, 2, Hai-yan LI1, 2, Lu LU1, 2, Xiao-wei LUO1, 2, Cheng-hai GAO1, 2, Yong-hong LIU1, 2, Zhao-he LUO3, *, Ren-hui LI4, Xin-ya XU1, 2, *
Acta Pharmaceutica Sinica | 2026, 61(4) : 1301 - 1305
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Acta Pharmaceutica Sinica | 2026, 61(4): 1301-1305
• Original Articles •
Okeanopeptin A, a new anabaenopeptin from marine cyanobacterium Okeanomitos corallinicola
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Hua-qing HUANG1, 2, Li-fen LIANG1, 2, Hai-yan LI1, 2, Lu LU1, 2, Xiao-wei LUO1, 2, Cheng-hai GAO1, 2, Yong-hong LIU1, 2, Zhao-he LUO3, *, Ren-hui LI4, Xin-ya XU1, 2, *
Affiliations
  • 1Institute of Marine Drugs/Guangxi Key Laboratory of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
  • 2University Engineering Research Center of High-Efficient Utilization of Marine Traditional Chinese Medicine Resources, Nanning 530200, China
  • 3School of Environmental Science and Engineering, Xiamen University of Technology, Xiamen 361024, China
  • 4College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China
Published: 2026-04-12 doi: 10.16438/j.0513-4870.2025-1231
Outline
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Cyanobacteria are an important source of novel chemical structures and bioactive lead compounds. A new anabaenopeptin, okeanopeptin A (1), was isolated from the culture products of a new genus of marine cyanobacterium Okeanomitos corallinicola. Its planar structure and absolute configuration were elucidated through extensive spectroscopic analysis including NMR and HRESIMS, as well as chemical derivatization. This compound represents the first reported anabaenopeptin incorporating an N-methylphenylalanine residue. Biological evaluation revealed that okeanopeptin A exhibited weak inhibitory activity against carboxypeptidase A.

marine cyanobacterium  /  Okeanomitos corallinicola  /  cyclic peptide  /  anabaenopeptin  /  carboxypeptidase A inhibition
黄华庆, 梁莉芬, 李海艳, 陆璐, 罗小卫, 高程海, 刘永宏, 罗肇河, 李仁辉, 徐新亚. 海洋蓝藻Okeanomitos corallinicola中的一个anabaenopeptin类新环肽okeanopeptin A. 药学学报, 2026 , 61 (4) : 1301 -1305 . DOI: 10.16438/j.0513-4870.2025-1231
Hua-qing HUANG, Li-fen LIANG, Hai-yan LI, Lu LU, Xiao-wei LUO, Cheng-hai GAO, Yong-hong LIU, Zhao-he LUO, Ren-hui LI, Xin-ya XU. Okeanopeptin A, a new anabaenopeptin from marine cyanobacterium Okeanomitos corallinicola[J]. Acta Pharmaceutica Sinica, 2026 , 61 (4) : 1301 -1305 . DOI: 10.16438/j.0513-4870.2025-1231
Appendix
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Year 2026 volume 61 Issue 4
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Article Info
doi: 10.16438/j.0513-4870.2025-1231
  • Receive Date：2025-10-16
  • Online Date：2026-09-21
  • Published：2026-04-12
Article Data
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History
  • Received：2025-10-16
  • Revised：2025-12-14
Affiliations
    1Institute of Marine Drugs/Guangxi Key Laboratory of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
    2University Engineering Research Center of High-Efficient Utilization of Marine Traditional Chinese Medicine Resources, Nanning 530200, China
    3School of Environmental Science and Engineering, Xiamen University of Technology, Xiamen 361024, China
    4College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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