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Overcoming the skin barrier: Advances in efficient transdermal delivery of traditional Chinese medicine
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Li-juan ZENG, Yu-ge WU, Ya-mei LI, Zhu-xian WANG, Qiang LIU*
Acta Pharmaceutica Sinica | 2026, 61(4) : 1107 - 1119
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Acta Pharmaceutica Sinica | 2026, 61(4): 1107-1119
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Overcoming the skin barrier: Advances in efficient transdermal delivery of traditional Chinese medicine
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Li-juan ZENG, Yu-ge WU, Ya-mei LI, Zhu-xian WANG, Qiang LIU*
Affiliations
  • School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China
Published: 2026-04-12 doi: 10.16438/j.0513-4870.2025-0775
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The transdermal delivery system of traditional Chinese medicine (TCM) has emerged as a vital alternative to conventional administration routes, particularly for chronic disease management, owing to its advantages in avoiding hepatic first-pass effects, maintaining stable blood drug concentrations, improving patient compliance, and enabling sustained release. However, the efficiency of TCM transdermal delivery is significantly constrained by the "brick-and-mortar structure" barrier of the stratum corneum and the inherent complexity of TCM components, which also complicates quality control and mechanistic studies. To address these challenges, innovative strategies have been developed in recent years, including microneedles, nanocarriers (liposomes, nanoemulsions, polymeric nanoparticles, nanocrystals and self-assembled nanomicelles), permeation enhancers, iontophoresis, and sonophoresis. Synergistic permeation-enhancing strategies further overcome limitations of single-technique approaches. These technologies demonstrate substantial clinical value in dermatological therapy, pain management, wound healing, and related fields.

traditional Chinese medicine  /  transdermal drug delivery  /  stratum corneum  /  penetration enhancer  /  new technology
曾莉娟, 吴雨歌, 李亚梅, 王著显, 刘强. 跨越皮肤屏障: 中药高效经皮递送的研究与应用探讨. 药学学报, 2026 , 61 (4) : 1107 -1119 . DOI: 10.16438/j.0513-4870.2025-0775
Li-juan ZENG, Yu-ge WU, Ya-mei LI, Zhu-xian WANG, Qiang LIU. Overcoming the skin barrier: Advances in efficient transdermal delivery of traditional Chinese medicine[J]. Acta Pharmaceutica Sinica, 2026 , 61 (4) : 1107 -1119 . DOI: 10.16438/j.0513-4870.2025-0775
Year 2026 volume 61 Issue 4
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252
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doi: 10.16438/j.0513-4870.2025-0775
  • Receive Date:2025-07-06
  • Online Date:2026-09-21
  • Published:2026-04-12
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  • Received:2025-07-06
  • Revised:2025-09-18
Affiliations
    School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
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Percentage of
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属
Genus
种数
Number of
species
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Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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