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Outline
Manganese dioxide (MnO2), as an intelligent drug carrier responsive to the tumor microenvironment (tumor microenvironment, TME), has recently garnered significant attention due to its unique physicochemical properties. However, the low specific surface area of conventional MnO2 materials severely limits their drug-loading capacity. In this study, three-dimensional urchin-like MnO2 nanomaterials were successfully synthesized through an optimized hydrothermal process, and a composite MnO2/Au nanoparticles (GNPs) system was constructed by immobilizing Au NPs onto the MnO2 surface via an impregnation method. Structural characterization revealed that the as-prepared urchin-like MnO2 exhibits a distinctive hollow-radial architecture with a specific surface area of 35.75 m2·g-1, significantly higher than that of conventional MnO2 materials (14-30 m2·g-1). Under near-infrared laser irradiation (808 nm, 2.5 W·cm-2), the composite demonstrated exceptional photothermal performance, achieving a temperature rise to 55 ℃ within 5 minutes and a calculated photothermal conversion efficiency of 61.85%. Drug-loading evaluations indicated a high loading efficiency of 81.3% for 5-fluorouracil, along with pH-responsive release characteristics, achieving 86.4% cumulative drug release within 2 h under simulated TME conditions (pH 5.0). By integrating morphology engineering and noble metal hybridization strategies, this work establishes a multifunctional nano-platform that combines high drug-loading capacity, controllable release, and efficient photothermal conversion, providing critical theoretical and technical foundations for developing synergistic chemo-photothermal therapeutic systems.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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