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The research progress on the diversified release strategies of resveratrol nano-delivery systems in tumor therapy
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Yu-tong MEI1, 2, Yu-han FU1, 2, Da-peng TONG1, 2, Wei-nan LI1, 2, *, Yan-hong WANG1, 2, *
Acta Pharmaceutica Sinica | 2026, 61(3) : 767 - 777
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Acta Pharmaceutica Sinica | 2026, 61(3): 767-777
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The research progress on the diversified release strategies of resveratrol nano-delivery systems in tumor therapy
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Yu-tong MEI1, 2, Yu-han FU1, 2, Da-peng TONG1, 2, Wei-nan LI1, 2, *, Yan-hong WANG1, 2, *
Affiliations
  • 1School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China
  • 2Key Laboratory of Basic and Application Research of Beiyao of the Ministry of Education, Harbin 150040, China
Published: 2026-03-12 doi: 10.16438/j.0513-4870.2025-0709
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Resveratrol (Res), a naturally non-flavonoid polyphenol, shows significant therapeutic potential in suppressing tumor growth, metastasis, and enhancing chemotherapy. However, Res has some disadvantages that limit its clinical use, such as low oral bioavailability, structural instability, and non-selective tissue distribution in vivo. Stimuli-responsive drug delivery systems can overcome these issues, achieving efficient delivery in vivo and controlled release at tumor-site. Based on the endogenous physiological features of tumors and exogenous stimulation methods, this paper uses Res as an example, which reviews the current response release methods for targeted delivery of anti-tumor drugs, such as pH, ROS, and light-responsive strategies, respectively. The diversified release designs offer references for controlled release of anti-tumor drugs in the complex tumor microenvironment. It also provides new ideas and directions for personalized and smart treatment for anti-tumor active ingredients from traditional Chinese medicine.

resveratrol  /  anti-tumor  /  endogenous stimulus-responsive release  /  exogenous stimulus-responsive release  /  nano-drug delivery system
梅雨桐, 付雨晗, 佟大鹏, 李伟男, 王艳宏. 白藜芦醇纳米递送系统在肿瘤治疗中多元化释放策略的研究进展. 药学学报, 2026 , 61 (3) : 767 -777 . DOI: 10.16438/j.0513-4870.2025-0709
Yu-tong MEI, Yu-han FU, Da-peng TONG, Wei-nan LI, Yan-hong WANG. The research progress on the diversified release strategies of resveratrol nano-delivery systems in tumor therapy[J]. Acta Pharmaceutica Sinica, 2026 , 61 (3) : 767 -777 . DOI: 10.16438/j.0513-4870.2025-0709
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Year 2026 volume 61 Issue 3
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Article Info
doi: 10.16438/j.0513-4870.2025-0709
  • Receive Date：2025-06-23
  • Online Date：2026-09-21
  • Published：2026-03-12
Article Data
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History
  • Received：2025-06-23
  • Revised：2025-08-10
Affiliations
    1School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China
    2Key Laboratory of Basic and Application Research of Beiyao of the Ministry of Education, Harbin 150040, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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