Full
Outline
Calcium/calmodulin-dependent protein kinase Ⅱ (CaMKⅡ) is a key enzyme mediating cardiac diseases such as arrhythmia, ischemic heart disease, and heart failure. Its involvement in the progression of cardiac diseases has become increasingly clear with advancing research. Targeted regulation of cardiac CaMKⅡ has become a major therapeutic strategy for heart diseases. However, traditional drug delivery strategies suffer from poor cardiac targeting and low local concentrations, necessitating the integration of innovative delivery and release systems. This review first describes the CaMKⅡ and its role in cardiac diseases, and then provides a systematic review of the design and research progress of cardiac-targeted nanodelivery systems, with the aim of offering new insights into the targeted regulation of cardiac CaMKⅡ and the development of innovative cardiac disease therapies.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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