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Outline
Since its introduction to the market, etomidate has held a significant position among intravenous anesthetics due to its favorable anesthetic properties and hemodynamic stability. However, adverse reactions like adrenocortical suppression and myoclonus have limited its clinical application. In recent years, the research on novel etomidate derivatives that can retain the excellent anesthetic characteristics of etomidate while significantly ameliorating its adverse effects has become a hot topic in the development of new anesthetic drugs. Through the structural modification of pharmacophores such as the carboxylic acid ester chain and imidazole ring, new derivatives, including ABP-700, EL-0052, ET-26, and NH600001, have been discovered. Some of these drugs have entered the phase Ⅲ clinical trial or NDA application stage, showing promising prospects for successful development and marketing approval. This article reviews the design strategies, preclinical research, and clinical research progress of etomidate derivatives, aiming to provide references for the development of new intravenous anesthetics.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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