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A new limonoid compound from the bark of Melia azedarach and its anti-hepatocarcinoma activity
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Yuan-yuan HUANG1, 2, 3, Er-jian GAO1, 2, 3, Jing-quan YUAN4, Yan-chun WU4, Xiao-ping RAO1, 2, 3, *, Wei WANG1, 2, 3, *
Acta Pharmaceutica Sinica | 2026, 61(2) : 547 - 552
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Acta Pharmaceutica Sinica | 2026, 61(2): 547-552
• Original Articles •
A new limonoid compound from the bark of Melia azedarach and its anti-hepatocarcinoma activity
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Yuan-yuan HUANG1, 2, 3, Er-jian GAO1, 2, 3, Jing-quan YUAN4, Yan-chun WU4, Xiao-ping RAO1, 2, 3, *, Wei WANG1, 2, 3, *
Affiliations
  • 1Institute of Advanced Carbon Conversion Technology, Huaqiao University, Xiamen 361021, China
  • 2Fujian Provincial Key Laboratory of Biomass Low-Carbon Conversion, Huaqiao University, Xiamen 361021, China
  • 3College of Chemical Engineering, Huaqiao University, Xiamen 361021, China
  • 4Institute of Traditional Chinese and Zhuang-Yao Ethnic Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China
Published: 2026-02-12 doi: 10.16438/j.0513-4870.2025-1252
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Three limonoids were isolated and purified from the 95%, 85% ethanol extracts of Melia azedarach using silica gel column chromatography, Sephadex LH-20 column chromatography, MCI column chromatography, and preparative RP-HPLC. Their structures were determined based on physicochemical properties and spectral data, and they were identified as 29-O-ethyl neoazedarachin D (1), 29-O-meliarachin G (2), toosendanin (3). Compound 1 is a new limonoid, while compound 2 is a new natural product isolated from plants for the first time. The in vitro anti-hepatocarcinoma activities of compounds 1-3 were evaluated by MTT assay. The results showed that compounds 1-3 exhibited different degrees of inhibitory effects on both HepG-2 and Hep3B cell lines, and the inhibitory effect of compound 3 on HepG-2 cells was comparable to that of the positive drug cisplatin. In addition, compounds 1-3 exhibited IC50 values of 38.67 ± 1.336, 28.21 ± 1.028 and 8.21 ± 1.231 μg·mL-1 against HepG-2 cells, and 47.36 ± 1.008, 35.69 ± 1.217 and 15.10 ± 1.017 μg·mL-1 against Hep3B cells, respectively.

Melia azedarach  /  limonoid  /  tetracyclic triterpenoid  /  structural identification  /  hepatocarcinoma
黄园园, 高尔建, 袁经权, 吴燕春, 饶小平, 王微. 苦楝皮中一个新的柠檬苦素类化合物及其抗肝癌活性. 药学学报, 2026 , 61 (2) : 547 -552 . DOI: 10.16438/j.0513-4870.2025-1252
Yuan-yuan HUANG, Er-jian GAO, Jing-quan YUAN, Yan-chun WU, Xiao-ping RAO, Wei WANG. A new limonoid compound from the bark of Melia azedarach and its anti-hepatocarcinoma activity[J]. Acta Pharmaceutica Sinica, 2026 , 61 (2) : 547 -552 . DOI: 10.16438/j.0513-4870.2025-1252
Appendix
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Year 2026 volume 61 Issue 2
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Article Info
doi: 10.16438/j.0513-4870.2025-1252
  • Receive Date：2025-10-21
  • Online Date：2026-09-21
  • Published：2026-02-12
Article Data
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History
  • Received：2025-10-21
  • Revised：2025-11-21
Affiliations
    1Institute of Advanced Carbon Conversion Technology, Huaqiao University, Xiamen 361021, China
    2Fujian Provincial Key Laboratory of Biomass Low-Carbon Conversion, Huaqiao University, Xiamen 361021, China
    3College of Chemical Engineering, Huaqiao University, Xiamen 361021, China
    4Institute of Traditional Chinese and Zhuang-Yao Ethnic Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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