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The chemical constituents of 50% acetone extract of the dried roots bark of Paeonia suffruticosa Andr. (Moutan Cortex) were isolated and purified using various column chromatographic methods, yielding 16 compounds. According to their physiochemical properties and spectral data, the structures of the isolated compounds were further identified as suffruticoside N (1), 1, 1′-[(1R)-2, 2′-dihydroxy-6, 6′-dimethoxy[1, 1′-biphenyl]-3, 3′-diyl]bis[ethanone] (2), 5-(1, 2-dihydroxy-1-methylethyl)-4-methylbicyclo[3.1.0]hexan-2-one (3), 4-(1, 2-dihydroxy-1-methylethyl)-1-cyclohexene-1-carboxylic acid (4), teutenone A (5), dihydroactinidiolide (6), cadina-4, 11-dien-14-oic acid (7), adenosine (8), uridine (9), methyl palmitate (10), 1-(3-hydroxy-4-methoxyphenyl)ethanone (11), 2, 4-dihydroxyacetophenone (12), methyl gallate (13), 2, 3-dihydroxybenzoic acid (14), benzoic acid (15), and pinoresinol (16). Compound 1 was a new biphenyl compound. Compounds 2 and 3 were two new natural products, and compounds 4 and 5 were firstly isolated from Moutan Cortex. Additionally, in preliminary vitro bioassays, all the isolated compounds were tested their inhibitory effects on acetylcholinesterase (AChE). As a result, compound 2 exhibited a moderate AChE with IC50 value of 15.7 ± 2.5 μmol·L-1.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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