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Two new sesquiterpene glycosides from the Lycii Cortex
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Ying LIU1, Cheng-yuan SU1, Shi-qing YOU1, Xiao-fei YANG1, Jia-yi WU1, Jia-hong LUO1, Fan-hang MENG1, Xin-yue YU1, Bin LIU1, 2, *, Wei ZHANG1, 2, *
Acta Pharmaceutica Sinica | 2026, 61(1) : 252 - 260
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Acta Pharmaceutica Sinica | 2026, 61(1): 252-260
• Original Articles •
Two new sesquiterpene glycosides from the Lycii Cortex
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Ying LIU1, Cheng-yuan SU1, Shi-qing YOU1, Xiao-fei YANG1, Jia-yi WU1, Jia-hong LUO1, Fan-hang MENG1, Xin-yue YU1, Bin LIU1, 2, *, Wei ZHANG1, 2, *
Affiliations
  • 1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China
  • 2The Key Research Laboratory of "Exploring Effective Substance in Classic and Famous Prescriptions of Traditional Chinese Medicine", The State Administration of Traditional Chinese Medicine of the People′s Republic of China, Beijing 102488, China
Published: 2026-01-12 doi: 10.16438/j.0513-4870.2025-0894
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Thirteen compounds were isolated from the Lycii Cortex by macroporous resin column chromatography, gel column chromatography and semi-preparative high performance liquid chromatography. The structures of the isolated compounds were identified by ultraviolet spectroscopy, infrared spectroscopy, nuclear magnetic resonance spectroscopy and mass spectrometry as solavetivone A (1), solavetivone B (2), 9-hydroxy-3-methoxy-6H-pyrido [1, 2-a] pyrazin-6-one (3), 5, 5′-di(2-ethyl-hexyloxy)-5, 5′-bifuran (4), bis(2-ethylhexyl) phthalate (5), scopoletin (6), periplogenin (7), 3β, 5β-dihydroxy-14-en-card-20(22)-enolide (8), (7R, 8S)-4-hydroxy-3, 5′-dimethoxy-4′, 7-epoxy-8, 3′-neoligna-9, 9′-diol-4-O-β-D-glucopyranosyl-(1→4)-β-D-glucopy-ranoside (9), 2-carbomethoxy 3-prenyl-1, 4-naphtho hydroquinone-1, 4-di-O-β-glucoside (10), 4-hydroxy-3-methoxyphenyl-β-D-xylopyranosyl (1→6)-O-β-D-glucopyranoside (11), syringic acid (12), vanillic acid (13). Compounds 1 and 2 were new sesquiterpene glycosides with solavetivone skeleton. Compounds 4, 8-10 were isolated from Solanaceae for the first time. The bioactive screening results indicate that compounds 1 and 2 do not exhibit inhibitory effects on NO production; however, they demonstrate weak inhibitory activity against α-glucosidase.

Lycii Cortex  /  chemical composition  /  sesquiterpene glycosides  /  Lycium chinense
刘莹, 苏成园, 尤诗晴, 杨晓菲, 吴嘉怡, 罗嘉宏, 孟凡航, 余新月, 刘斌, 张薇. 地骨皮中2个新的倍半萜苷类化合物. 药学学报, 2026 , 61 (1) : 252 -260 . DOI: 10.16438/j.0513-4870.2025-0894
Ying LIU, Cheng-yuan SU, Shi-qing YOU, Xiao-fei YANG, Jia-yi WU, Jia-hong LUO, Fan-hang MENG, Xin-yue YU, Bin LIU, Wei ZHANG. Two new sesquiterpene glycosides from the Lycii Cortex[J]. Acta Pharmaceutica Sinica, 2026 , 61 (1) : 252 -260 . DOI: 10.16438/j.0513-4870.2025-0894
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Year 2026 volume 61 Issue 1
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Article Info
doi: 10.16438/j.0513-4870.2025-0894
  • Receive Date：2025-07-29
  • Online Date：2026-09-21
  • Published：2026-01-12
Article Data
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History
  • Received：2025-07-29
  • Revised：2025-11-07
Affiliations
    1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China
    2The Key Research Laboratory of "Exploring Effective Substance in Classic and Famous Prescriptions of Traditional Chinese Medicine", The State Administration of Traditional Chinese Medicine of the People′s Republic of China, Beijing 102488, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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