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Outline
Plant-derived extracellular vesicles are a kind of nanoscale vesicles with lipid bilayer membrane structure actively secreted by plant cells. As important media for intercellular communication in plants, extracellular vesicles are rich in a variety of biologically active molecules, including nucleic acids, proteins and lipids, and play key roles in intercellular material transport and information transmission. Due to excellent biocompatibility, low immunogenicity and natural cross-species delivery ability, plant-derived extracellular vesicles have become an ideal choice for new drug delivery carriers, which can efficiently load nucleic acid drugs, protein preparations and hydrophobic drug molecules. In recent years, with the rapid development of nanomedicine technology, the application of plant-derived extracellular vesicles in targeted drug delivery systems has made significant progress. This review systematically summarizes the separation and purification technology, stability, targeting, drug loading strategy of plant-derived extracellular vesicles and their latest application results as drug delivery carriers, in order to provide theoretical reference for related research.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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