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Research progress on the interaction mechanism of glucose and lipid metabolism and intervention strategies in rheumatoid arthritis
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Ying WANG1, Yan-hong BU1, *, Jing PANG2, Hong WU2, *
Acta Pharmaceutica Sinica | 2025, 60(12) : 3655 - 3664
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Acta Pharmaceutica Sinica | 2025, 60(12): 3655-3664
• Reviews •
Research progress on the interaction mechanism of glucose and lipid metabolism and intervention strategies in rheumatoid arthritis
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Ying WANG1, Yan-hong BU1, *, Jing PANG2, Hong WU2, *
Affiliations
  • 1School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230012, China
  • 2Anhui Province Key Laboratory of Research and Development of Chinese Medicine, Key Lab of Xin′an Medicine, Ministry of Education, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
Published: 2025-12-12 doi: 10.16438/j.0513-4870.2025-0601
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Rheumatoid arthritis (RA), a chronic autoimmune disease, has a complex interaction with glucose and lipid metabolism in pathological process. Glucose metabolism reprogramming disrupts the metabolic homeostasis of the microenvironment and activates aerobic glycolysis to drive synovial proliferation and inflammation; lipid metabolism dysfunction reshapes the inflammatory regulatory network through lipid-derived mediators. The interplay between glucose and lipid metabolism jointly drives the "metabolism-inflammation" vicious cycle, in which the metabolic hub role of acetyl coenzyme A, the bidirectional regulatory role of lactate, the synergistic regulation of metabolic signals, and the organelle interaction between mitochondria and lipid droplets collectively exacerbate the pathological progression of RA. This review systematically focuses on the abnormal characteristics and interaction mechanisms of the two core pathways of glucose and lipid metabolism in RA, proposes intervention strategies and research directions targeting metabolic homeostasis based on metabolic targets, and provides important scientific references for the in-depth analysis of the pathological mechanism of RA and the development of targeted metabolic intervention therapies.

glucose and lipid metabolism  /  rheumatoid arthritis  /  metabolism reprogramming  /  inflammation  /  metabolic intervention therapy
王影, 卜妍红, 庞静, 吴虹. 类风湿关节炎中糖脂代谢交互机制与干预策略的研究进展. 药学学报, 2025 , 60 (12) : 3655 -3664 . DOI: 10.16438/j.0513-4870.2025-0601
Ying WANG, Yan-hong BU, Jing PANG, Hong WU. Research progress on the interaction mechanism of glucose and lipid metabolism and intervention strategies in rheumatoid arthritis[J]. Acta Pharmaceutica Sinica, 2025 , 60 (12) : 3655 -3664 . DOI: 10.16438/j.0513-4870.2025-0601
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Year 2025 volume 60 Issue 12
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Article Info
doi: 10.16438/j.0513-4870.2025-0601
  • Receive Date：2025-05-27
  • Online Date：2026-09-20
  • Published：2025-12-12
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History
  • Received：2025-05-27
  • Revised：2025-07-22
Affiliations
    1School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230012, China
    2Anhui Province Key Laboratory of Research and Development of Chinese Medicine, Key Lab of Xin′an Medicine, Ministry of Education, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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