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Advances in microneedle therapy for tumor treatment based on stimulus responsiveness
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Dan LI1, Shao-hua XU1, Mu-lan LI1, Xiao-xia LIU1, Ming YANG2, *, Fang WANG1, 2, *
Acta Pharmaceutica Sinica | 2025, 60(12) : 3730 - 3741
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Acta Pharmaceutica Sinica | 2025, 60(12): 3730-3741
• Reviews •
Advances in microneedle therapy for tumor treatment based on stimulus responsiveness
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Dan LI1, Shao-hua XU1, Mu-lan LI1, Xiao-xia LIU1, Ming YANG2, *, Fang WANG1, 2, *
Affiliations
  • 1Cancer Research Center, Jiangxi University of Chinese Medicine, Nanchang 330004, China
  • 2Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Published: 2025-12-12 doi: 10.16438/j.0513-4870.2025-0243
Outline
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The application of microneedle technology in biomedicine has attracted widespread attention due to its versatility in tissue sampling, biosensing and drug delivery. In particular, drug-loaded microneedle formulations can directly penetrate the stratum corneum to deliver drugs, enhance drug delivery efficiency, and achieve the purpose of disease treatment, which is characterized by high efficiency, portability, low trauma, and high controllability. When combined with smart responsive materials, microneedles enable precise drug delivery, improving targeting accuracy for diseases such as tumors while minimizing toxic side effects on normal tissues and cells. In this review, we introduce the history of microneedle technology and highlight its applications in smart-responsive systems for oncology therapy. We also discuss the current challenges and obstacles faced by microneedle technology in oncology therapy and clinical translation. Finally, we provide prospective recommendations on the current situation, aiming to inspire new ideas and directions for the development of related technologies.

stimulus responsiveness  /  microneedle  /  transdermal drug delivery  /  tumor therapy  /  tumor microenvironment
李丹, 许梢华, 李木兰, 刘晓霞, 杨明, 王芳. 基于刺激响应性的微针治疗肿瘤的研究进展. 药学学报, 2025 , 60 (12) : 3730 -3741 . DOI: 10.16438/j.0513-4870.2025-0243
Dan LI, Shao-hua XU, Mu-lan LI, Xiao-xia LIU, Ming YANG, Fang WANG. Advances in microneedle therapy for tumor treatment based on stimulus responsiveness[J]. Acta Pharmaceutica Sinica, 2025 , 60 (12) : 3730 -3741 . DOI: 10.16438/j.0513-4870.2025-0243
Year 2025 volume 60 Issue 12
238
116
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Article Info
doi: 10.16438/j.0513-4870.2025-0243
  • Receive Date:2025-03-06
  • Online Date:2026-09-20
  • Published:2025-12-12
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History
  • Received:2025-03-06
  • Revised:2025-07-09
Affiliations
    1Cancer Research Center, Jiangxi University of Chinese Medicine, Nanchang 330004, China
    2Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
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Percentage of
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属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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