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Target fishing technologies in traditional Chinese medicines: mechanisms and applications for four chronic diseases
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Ke-jia XU1, Quan LIU1, Jia-xuan ZHAO1, Chen-wei ZUO2, Hui CAO1, Chen-yang LI3, Lei LEI1, Cai-na LI1, Ruo-fei DU4, 5, Yi HUAN1, Zhu-fang SHEN1, Yu TIAN2, *, Shuai-nan LIU1, *
Acta Pharmaceutica Sinica | 2025, 60(11) : 3371 - 3380
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Acta Pharmaceutica Sinica | 2025, 60(11): 3371-3380
• Reviews •
Target fishing technologies in traditional Chinese medicines: mechanisms and applications for four chronic diseases
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Ke-jia XU1, Quan LIU1, Jia-xuan ZHAO1, Chen-wei ZUO2, Hui CAO1, Chen-yang LI3, Lei LEI1, Cai-na LI1, Ruo-fei DU4, 5, Yi HUAN1, Zhu-fang SHEN1, Yu TIAN2, *, Shuai-nan LIU1, *
Affiliations
  • 1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China
  • 2State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-Di Herbs, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, China
  • 3School of Pharmacy, Shenzhen University Health Science Center, Shenzhen 518055, China
  • 4Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • 5Engineering Research Center of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Shanghai 201203, China
Published: 2025-11-12 doi: 10.16438/j.0513-4870.2025-0372
Outline
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Traditional Chinese medicines (TCMs), with its rich historical legacy and demonstrated efficacy in treating chronic non-communicable diseases, particularly in addressing cancer, cardiovascular diseases, diabetes, and chronic respiratory diseases, presents unique challenges for scientific investigation due to its complex chemical composition and poorly understood mechanisms of action. This review systematically examines the evolution of target fishing technology, evaluates established target identification technology and ligand fishing technology in TCMs research, and synthesizes recent advancements in applying these methodologies to elucidate the therapeutic mechanisms of TCMs for major chronic diseases, with special emphasis on component-target interactions. By providing a critical analysis of current applications and future directions, this work aims to advance the integration of target fishing technologies into modern TCMs research and establish a robust framework for mechanistic studies in this field.

target fishing  /  traditional Chinese medicine  /  target identification  /  ligand fishing  /  chronic non-communicable disease
许珂嘉, 刘泉, 赵佳璇, 左晨伟, 曹慧, 李晨阳, 雷蕾, 李彩娜, 杜若飞, 环奕, 申竹芳, 田瑜, 刘率男. 基于靶向垂钓技术挖掘传统中药治疗四大慢病的作用机制研究进展. 药学学报, 2025 , 60 (11) : 3371 -3380 . DOI: 10.16438/j.0513-4870.2025-0372
Ke-jia XU, Quan LIU, Jia-xuan ZHAO, Chen-wei ZUO, Hui CAO, Chen-yang LI, Lei LEI, Cai-na LI, Ruo-fei DU, Yi HUAN, Zhu-fang SHEN, Yu TIAN, Shuai-nan LIU. Target fishing technologies in traditional Chinese medicines: mechanisms and applications for four chronic diseases[J]. Acta Pharmaceutica Sinica, 2025 , 60 (11) : 3371 -3380 . DOI: 10.16438/j.0513-4870.2025-0372
Appendix
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Year 2025 volume 60 Issue 11
297
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Article Info
doi: 10.16438/j.0513-4870.2025-0372
  • Receive Date：2025-04-02
  • Online Date：2026-09-20
  • Published：2025-11-12
Article Data
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History
  • Received：2025-04-02
  • Revised：2025-07-05
Affiliations
    1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China
    2State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-Di Herbs, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, China
    3School of Pharmacy, Shenzhen University Health Science Center, Shenzhen 518055, China
    4Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    5Engineering Research Center of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Shanghai 201203, China
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表12种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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