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Twelve compounds were isolated and purified from Fissistigma polyanthum by using various modern separation techniques such as silica gel, MCI, ODS, and Sephadex LH-20 column chromatography, as well as preparative HPLC. The structures of these compounds were determined by spectroscopic methods and identified as fissistigmaoid A (1), (10S)-11-hydroxy-β-cyperone (2), 11-hydroxy-8-oxo-β-cyperone (3), (4S, 5E, 10R)-7-oxo-tri-nor-eudesm-5-en-4β-ol (4), oxyphyllanene B (5), teuhetone (6), teuhetenone A (7), trans-4, 5-dihydroxycorocalane (8), 4-hydroxy-4, 7-dimethyl-1-tetralone (9), epicatechin (10), dihydroquercetin (11), and piperolactam C (12). Among them, compound 1 is a new nor-eudesmane-type sesquiterpene, while compounds 1-9 were isolated from F. polyanthum for the first time. Compounds 8 and 12 exhibited NO inhibitory activity in an LPS-induced RAW 264.7 murine macrophage inflammation model, with IC50 values of 30.5 ± 1.5 and 10.5 ± 1.0 μmol·L-1 respectively.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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