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3D printing of oral solid dosage forms: research and applications of printing materials
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Zhi-qiang TANG1, 2, Jie WU3, Xiao-xuan HONG2, Xiao-lu HAN2, Shu-wei DUAN3, Hui ZHANG2, Nan LIU2, Zeng-ming WANG2, *, Ai-ping ZHENG2, *
Acta Pharmaceutica Sinica | 2025, 60(9) : 2776 - 2787
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Acta Pharmaceutica Sinica | 2025, 60(9): 2776-2787
• Reviews •
3D printing of oral solid dosage forms: research and applications of printing materials
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Zhi-qiang TANG1, 2, Jie WU3, Xiao-xuan HONG2, Xiao-lu HAN2, Shu-wei DUAN3, Hui ZHANG2, Nan LIU2, Zeng-ming WANG2, *, Ai-ping ZHENG2, *
Affiliations
  • 1College of Pharmacy, Yanbian University, Yanji 133002, China
  • 2State Key Laboratory of National Security Specially Needed Medicines, Academy of Military Medical Sciences, Beijing 100850, China
  • 3First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
Published: 2025-09-12 doi: 10.16438/j.0513-4870.2024-0145
Outline
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With the introduction of the concept of precision medicine, pharmaceutical treatment is shifting from 'one-size-fits-all' to personalization, and 3D printing, as an emerging formulation technology, can significantly enhance the complexity and flexibility of formulations, solve the many problems of the traditional process, and achieve personalized drug therapy. In recent years, with the rapid development of 3D printing technology, various 3D printing technologies have been used to develop oral solid dosage forms. Given the differences in the types and characteristics of 3D printing technologies, it is necessary to select appropriate printing materials according to the application characteristics of printing technology, and the choice of materials can significantly impact the personalized shaping and precise release of oral solid dosage forms. This paper lists the principles and characteristics of fused deposition molding technology, semi-solid extrusion technology, melt extrusion deposition technology, and binder jetting technology, which is suitable for the 3D printing of oral solid preparations. It explores the selection and application of printing materials for commonly used 3D printing technologies in detail to guide the choice of materials to prepare different principles of 3D printing of oral solid preparations.

oral solid dosage form  /  3D printing technology  /  personalization customization  /  printing material  /  formulation moldability  /  precise drug release
唐志强, 吴杰, 洪晓轩, 韩晓璐, 段姝伟, 张慧, 刘楠, 王增明, 郑爱萍. 3D打印口服固体制剂: 打印材料的研究应用. 药学学报, 2025 , 60 (9) : 2776 -2787 . DOI: 10.16438/j.0513-4870.2024-0145
Zhi-qiang TANG, Jie WU, Xiao-xuan HONG, Xiao-lu HAN, Shu-wei DUAN, Hui ZHANG, Nan LIU, Zeng-ming WANG, Ai-ping ZHENG. 3D printing of oral solid dosage forms: research and applications of printing materials[J]. Acta Pharmaceutica Sinica, 2025 , 60 (9) : 2776 -2787 . DOI: 10.16438/j.0513-4870.2024-0145
Year 2025 volume 60 Issue 9
272
141
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Article Info
doi: 10.16438/j.0513-4870.2024-0145
  • Receive Date:2024-02-20
  • Online Date:2026-09-20
  • Published:2025-09-12
Article Data
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History
  • Received:2024-02-20
  • Revised:2024-12-12
Affiliations
    1College of Pharmacy, Yanbian University, Yanji 133002, China
    2State Key Laboratory of National Security Specially Needed Medicines, Academy of Military Medical Sciences, Beijing 100850, China
    3First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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