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Chinese herbal medicine-derived extracellular vesicles: a new strategy for regulating metabolism and synergistic immunity
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Jing-huang WANG1, 2, Zhi-wen YI1, 2, Kuan-han FENG1, 2, Fu-cai CHEN1, 2, Liu-qing DI1, 2, Ruo-ning WANG1, 2, *
Acta Pharmaceutica Sinica | 2025, 60(9) : 2730 - 2739
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Acta Pharmaceutica Sinica | 2025, 60(9): 2730-2739
• Reviews •
Chinese herbal medicine-derived extracellular vesicles: a new strategy for regulating metabolism and synergistic immunity
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Jing-huang WANG1, 2, Zhi-wen YI1, 2, Kuan-han FENG1, 2, Fu-cai CHEN1, 2, Liu-qing DI1, 2, Ruo-ning WANG1, 2, *
Affiliations
  • 1School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 2Jiangsu Provincial TCM Engineering Technology Research Center of High Efficient Drug Delivery System, Nanjing 210023, China
Published: 2025-09-12 doi: 10.16438/j.0513-4870.2025-0678
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Compared with normal cells, tumor cells exhibit unique metabolic characteristics. The therapeutic strategies formulated based on the energy metabolic features of tumors aim to block the energy and material supply of tumor cells at the source, remodel the immunosuppressive tumor microenvironment (TME), and create favorable conditions for immune cell infiltration and function. In recent years, Chinese herbal medicine-derived extracellular vesicles have attracted attention due to their unique metabolic regulatory capabilities and targeting properties. These extracellular vesicles can not only precisely deliver multi-component active molecules but also reprogram the metabolic processes in the tumor microenvironment, reverse immunosuppressive conditions, and thereby enhance antitumor immune responses. This review systematically summarizes the metabolic regulatory mechanisms of TCM-derived vesicles and their synergistic effects in immunotherapy, and looks forward to their clinical transformation potential and future research directions.

Chinese herbal medicine-derived extracellular vesicle  /  metabolic regulation  /  immune synergy  /  tumor microenvironment  /  multicomponent delivery
王竞凰, 易志文, 封宽瀚, 陈富财, 狄留庆, 王若宁. 中草药囊泡: 调控代谢增效免疫的肿瘤治疗新策略. 药学学报, 2025 , 60 (9) : 2730 -2739 . DOI: 10.16438/j.0513-4870.2025-0678
Jing-huang WANG, Zhi-wen YI, Kuan-han FENG, Fu-cai CHEN, Liu-qing DI, Ruo-ning WANG. Chinese herbal medicine-derived extracellular vesicles: a new strategy for regulating metabolism and synergistic immunity[J]. Acta Pharmaceutica Sinica, 2025 , 60 (9) : 2730 -2739 . DOI: 10.16438/j.0513-4870.2025-0678
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Year 2025 volume 60 Issue 9
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Article Info
doi: 10.16438/j.0513-4870.2025-0678
  • Receive Date：2025-06-17
  • Online Date：2026-09-20
  • Published：2025-09-12
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History
  • Received：2025-06-17
  • Revised：2025-07-09
Affiliations
    1School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
    2Jiangsu Provincial TCM Engineering Technology Research Center of High Efficient Drug Delivery System, Nanjing 210023, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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