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Advances in novel drug discovery from marine echinoderm polysaccharides: isolation and preparation, structural elucidation, and pharmacological activity
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Zi-dong LIU1, Jie-wen FU1, Xiang SHI1, 2, Xue-dong ZHANG1, Yong-hong LIU1, Qing-xia YUAN1, *, Long-yan ZHAO1, *
Acta Pharmaceutica Sinica | 2025, 60(7) : 2106 - 2121
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Acta Pharmaceutica Sinica | 2025, 60(7): 2106-2121
• Reviews •
Advances in novel drug discovery from marine echinoderm polysaccharides: isolation and preparation, structural elucidation, and pharmacological activity
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Zi-dong LIU1, Jie-wen FU1, Xiang SHI1, 2, Xue-dong ZHANG1, Yong-hong LIU1, Qing-xia YUAN1, *, Long-yan ZHAO1, *
Affiliations
  • 1Guangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
  • 2College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China
Published: 2025-07-12 doi: 10.16438/j.0513-4870.2025-0079
Outline
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Polysaccharides from marine organisms are an important source for researching and developing innovative carbohydrate-based drugs. Echinoderms, such as sea cucumber, starfish, sea urchin, and brittle star, are rich in resources. The polysaccharides from these species exhibit unique structural features and possess extensive, potent pharmacological activities, making them promising lead compounds for carbohydrate drug development. In recent years, significant progress has been made in the isolation and purification, structural analysis, and activity evaluation of marine echinoderm polysaccharides. Notably, the fine structures of several polysaccharides have been elucidated, and several novel polysaccharides with nanomolar-level activity have been identified. However, numerous challenges and deficiencies remain in the research areas related to structural elucidation, structure-activity relationships, and mechanisms of action. This review systematically summarizes the progress and breakthroughs in the study of marine echinoderm polysaccharides and provides new insights and suggestions, which may offer important reference information for the research and development of low-toxicity, high-efficiency marine carbohydrate drugs, thereby advancing the field of marine-derived pharmaceuticals.

marine echinoderm  /  marine drug  /  polysaccharides  /  oligosaccharide  /  structure-activity relationship
刘梓栋, 符洁雯, 时响, 张雪冬, 刘永宏, 袁清霞, 赵龙岩. 海洋棘皮动物多糖新药挖掘进展: 分离制备、结构解析及药理活性. 药学学报, 2025 , 60 (7) : 2106 -2121 . DOI: 10.16438/j.0513-4870.2025-0079
Zi-dong LIU, Jie-wen FU, Xiang SHI, Xue-dong ZHANG, Yong-hong LIU, Qing-xia YUAN, Long-yan ZHAO. Advances in novel drug discovery from marine echinoderm polysaccharides: isolation and preparation, structural elucidation, and pharmacological activity[J]. Acta Pharmaceutica Sinica, 2025 , 60 (7) : 2106 -2121 . DOI: 10.16438/j.0513-4870.2025-0079
Year 2025 volume 60 Issue 7
233
115
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Article Info
doi: 10.16438/j.0513-4870.2025-0079
  • Receive Date:2025-01-20
  • Online Date:2026-09-20
  • Published:2025-07-12
Article Data
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History
  • Received:2025-01-20
  • Revised:2025-04-27
Affiliations
    1Guangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
    2College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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