Full
Outline
Ferroptosis, a form of non-apoptotic cell death, mainly depends on iron and reactive oxygen species (ROS) to trigger oxidative-reduction imbalance, causing membrane lipid peroxidation, cell membrane damage, and subsequent cell death. Recently, its crucial roles in embryonic development, metabolic regulation, neurodegenerative diseases, and cancer therapy have been unveiled. This article delves into the dynamic balance of cell membrane lipid peroxidation injury and repair mechanisms during ferroptosis, and dissects the multifaceted functions of mitochondria, lysosomes, etc., in regulating ferroptosis. The imbalance between membrane damage and repair is a hallmark of ferroptosis. The antioxidant system maintains membrane integrity by regulating lipid metabolism and redox homeostasis, while membrane repair mechanisms prevent cell death by removing lipid peroxides. Moreover, organelles interact dynamically through iron metabolism, ROS signaling, and lipid peroxide diffusion, modulating ferroptosis sensitivity. This article encapsulates the latest progress in ferroptosis mechanisms and highlights the potential of targeting membrane repair and organelle interactions for disease therapy, offering novel insights for precise disease intervention.
284
133
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
