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Research progress on the compatibility mechanisms and innovative formulation design and application of Glycyrrhizae Radix et Rhizoma based on molecular self-assembly
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Fang-wen CHEN1, 2, 3, Feng-xia WANG1, 2, 3, Shuang-chen ZHANG1, 2, 3, Nian-zhan ZHANG1, 2, 3, Cheng-ying SHEN4, Peng-fei YUE1, 2, 3, *, Bao-de SHEN1, 2, 3, *
Acta Pharmaceutica Sinica | 2025, 60(7) : 2158 - 2166
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Acta Pharmaceutica Sinica | 2025, 60(7): 2158-2166
• Reviews •
Research progress on the compatibility mechanisms and innovative formulation design and application of Glycyrrhizae Radix et Rhizoma based on molecular self-assembly
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Fang-wen CHEN1, 2, 3, Feng-xia WANG1, 2, 3, Shuang-chen ZHANG1, 2, 3, Nian-zhan ZHANG1, 2, 3, Cheng-ying SHEN4, Peng-fei YUE1, 2, 3, *, Bao-de SHEN1, 2, 3, *
Affiliations
  • 1Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China
  • 2State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang 330004, China
  • 3Research and Development Department, Jiangzhong Pharmaceutical Co., Ltd., Nanchang 330004, China
  • 4Department of Pharmacy, Jiangxi Provincial People′s Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, China
Published: 2025-07-12 doi: 10.16438/j.0513-4870.2025-0068
Outline
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Glycyrrhizae Radix et Rhizoma (GRR) is widely used in ancient and modern Chinese herbal compounds, which can moderate property of herbs with the effect of improving efficacy and reducing toxicity. Exploring the scientific connotation of GRR compatibility theory is of great significance for guiding the clinical application of GRR compatibility and related drug development. Based on summarizing the application and research status of GRR compatibility, this paper mainly reviews the research progress on the mechanisms of GRR compatibility in terms of enhancing efficiency, alleviating property, reducing toxicity, and incompatibility from the perspective of molecular self-assembly, and simultaneously expounds on the research progress of innovative formulation design and application of GRR components based on molecular self-assembly, so as to provide reference and guidance for further explaining and enriching the scientific connotation of GRR compatibility theory, and to provide certain theoretical and practical basis for the design and development of innovative formulations based on GRR component self-assembly.

Glycyrrhizae Radix et Rhizoma  /  self-assembly  /  compatibility mechanism  /  synergy and attenuation  /  drug incompatibility  /  pharmaceutical design
陈芳雯, 王凤霞, 张双辰, 张年战, 沈成英, 岳鹏飞, 申宝德. 基于分子自组装的甘草配伍机制及其创新制剂设计与应用研究进展. 药学学报, 2025 , 60 (7) : 2158 -2166 . DOI: 10.16438/j.0513-4870.2025-0068
Fang-wen CHEN, Feng-xia WANG, Shuang-chen ZHANG, Nian-zhan ZHANG, Cheng-ying SHEN, Peng-fei YUE, Bao-de SHEN. Research progress on the compatibility mechanisms and innovative formulation design and application of Glycyrrhizae Radix et Rhizoma based on molecular self-assembly[J]. Acta Pharmaceutica Sinica, 2025 , 60 (7) : 2158 -2166 . DOI: 10.16438/j.0513-4870.2025-0068
Appendix
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Year 2025 volume 60 Issue 7
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Article Info
doi: 10.16438/j.0513-4870.2025-0068
  • Receive Date：2025-01-19
  • Online Date：2026-09-20
  • Published：2025-07-12
Article Data
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History
  • Received：2025-01-19
  • Revised：2025-05-26
Affiliations
    1Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China
    2State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang 330004, China
    3Research and Development Department, Jiangzhong Pharmaceutical Co., Ltd., Nanchang 330004, China
    4Department of Pharmacy, Jiangxi Provincial People′s Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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