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The 95% ethanol extract of llicium micranthum was separated and purified by silica gel, Sephadex LH-20, MCI-gel and semi-preparative HPLC. The chemical structures of the isolated compounds were identified by NMR and MS. Twelve compounds were isolated and identified as illimicranol A (1), vanilloloside (2), 4-O-β-D-glucosyl-benzoic acid (3), gastrodin (4), icariside D2 (5), caryolane-1,9β-diol (6), clovane-2β,9α-diol (7), methyl shikimate (8), protocatechuic acid methyl ester (9), p-hydroxybenzyl alcohol (10), p-hydroxyphenylethanol (11), methyl p-hydroxyphenylacetate (12). Among them, compound 1 is a unique lignan with new carbon skeleton, named illimicranol A. Compounds 2-12 are firstly isolated from this plant. The effects of compound 1 on the differentiation of PC12 cells induced by NGF and the damage of PC12 cells induced by MPP+ were evaluated. The results showed that compound 1 did not exhibit obvious neurotrophic and neuroprotective activities.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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