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A new flavonone from Epimedium sagittatum Maxim and its anti-pulmonary fibrosis activity
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Xiang YU1, 2, Shuang-shuang XIE1, 2, Ru WANG1, 2, Meng-nan ZENG1, 2, Xiao-ke ZHENG1, 2, Wei-sheng FENG1, 2, *
Acta Pharmaceutica Sinica | 2025, 60(8) : 2561 - 2565
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Acta Pharmaceutica Sinica | 2025, 60(8): 2561-2565
• Original Articles •
A new flavonone from Epimedium sagittatum Maxim and its anti-pulmonary fibrosis activity
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Xiang YU1, 2, Shuang-shuang XIE1, 2, Ru WANG1, 2, Meng-nan ZENG1, 2, Xiao-ke ZHENG1, 2, Wei-sheng FENG1, 2, *
Affiliations
  • 1School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou 450046, China
Published: 2025-08-12 doi: 10.16438/j.0513-4870.2025-0231
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Five compounds were isolated from the dichloromethane fraction of a 70% ethanol extract of Epimedium sagittatum Maxim using a combination of chromatography techniques, including silica gel column chromatography, ODS column chromatography, and semipreparative high-performance liquid chromatography techniques. The structures of these five compounds were identified as 5,4′-dihydroxy-3′-prenyl-7-prenyloxyflavanone (1), 5,4′-dihydroxy-7-prenyloxyflavanone (2), 5,7,4′-trihydroxy-3′,8-diprenylflavanone (3), sebacic acid (4), and aurantiamide acetate (5), respectively, based on a comprehensive analysis of their physicochemical properties and spectroscopic data, such as NMR and MS. Notably, compound 1 was found to be a new flavonone compound, while compounds 2-5 were isolated from the Epimedium genus for the first time. Additionally, preliminary investigations indicated that compounds 1 and 3 exhibited potential anti-pulmonary fibrosis activities.

Berberidaceae  /  Epimedium sagittatum Maxim  /  flavonone  /  structure identification  /  anti-pulmonary fibrosis
喻翔, 解双双, 王茹, 曾梦楠, 郑晓珂, 冯卫生. 箭叶淫羊藿中一个新的二氢黄酮类化合物及其抗肺纤维化活性研究. 药学学报, 2025 , 60 (8) : 2561 -2565 . DOI: 10.16438/j.0513-4870.2025-0231
Xiang YU, Shuang-shuang XIE, Ru WANG, Meng-nan ZENG, Xiao-ke ZHENG, Wei-sheng FENG. A new flavonone from Epimedium sagittatum Maxim and its anti-pulmonary fibrosis activity[J]. Acta Pharmaceutica Sinica, 2025 , 60 (8) : 2561 -2565 . DOI: 10.16438/j.0513-4870.2025-0231
Year 2025 volume 60 Issue 8
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Article Info
doi: 10.16438/j.0513-4870.2025-0231
  • Receive Date:2025-03-03
  • Online Date:2026-09-20
  • Published:2025-08-12
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  • Received:2025-03-03
  • Revised:2025-05-16
Affiliations
    1School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
    2The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou 450046, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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