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Outline
Gut microbiota, the largest microbial community in the body, plays an important role in maintaining the immune homeostasis of the intestinal system and even the extraintestinal organs. Recently, increasing evidence has highlighted the substantial impact of gut microbiota on the cancer progression and therapy. Intervention of gut microbiota is considered as a promising anti-tumor strategy. Though the molecular mechanisms remain mostly unknown, it is widely appreciated that microbiota-derived metabolites critically mediate the interplay between host and microbiota, triggering enthusiasm to understand the mechanism behind. This article summarizes the latest progress in understanding mechanisms of microbial metabolites in regulating host immune responses, in particular in antitumor immunity. With this, we hope to provide insights for new therapeutics from the perspective of microbiota intervention.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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