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Outline
To address the growing global challenge of antibiotic resistance, the development of novel drug formulations with high specificity, excellent antibacterial activity, and the ability to reduce the generation of bacterial resistance has become an urgent and critical task. Recently, new molecular materials with aggregation-induced emission (AIE) properties have shown great potential in disease treatment due to their unique luminescent properties and high biocompatibility. By combining phage therapy with AIE-based photodynamic therapy (PDT), a new antibacterial strategy, known as AIE-armed phages, has been developed. This innovative approach not only enables bacterial imaging in vivo but also enhances targeted bacterial eradication through the synergistic effects of PDT and phage therapy. This review summarizes the research progress of AIE-armed phages, highlighting the unique targeting and visualization capabilities of this biological conjugate, demonstrating its potential to precisely locate and effectively eliminate bacteria, and discusses future directions for optimizing AIE-armed phages.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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