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Identification of chemical constituents in Aster tataricus by UHPLC-Q-TOF-MS
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Yi-jun CHEN1, 2, Hao WU1, Zi-yi WEI1, Lian-ming CHEN1, Jiao-jiao DONG1, Jie LIU3, Zhi-xin JIA3, Hong-bin XIAO1, 2, *
Acta Pharmaceutica Sinica | 2019, 54(9) : 1645 - 1654
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Acta Pharmaceutica Sinica | 2019, 54(9): 1645-1654
• Original Articles •
Identification of chemical constituents in Aster tataricus by UHPLC-Q-TOF-MS
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Yi-jun CHEN1, 2, Hao WU1, Zi-yi WEI1, Lian-ming CHEN1, Jiao-jiao DONG1, Jie LIU3, Zhi-xin JIA3, Hong-bin XIAO1, 2, *
Affiliations
  • 1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China
  • 2. Beijing Key Laboratory of Syndrome Prescription Basic Research, Beijing University of Chinese Medicine, Beijing 100029, China
  • 3. Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
Published: 2019-09-12 doi: 10.16438/j.0513-4870.2019-0214
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The root of Aster tataricus L. f. (RA) has been widely used in the clinic for moistening lung, dispelling phlegm and relieving cough because of its significant therapeutic effects on respiratory diseases. In this study, a systematic data acquisition and mining strategy was established aimed at solving the complexity of the traditional Chinese medicine using ultra high performance liquid chromatography coupled with quadruple time of flight mass spectrometry (UHPLC-Q-TOF-MS). A total of 132 chemical constituents, including 43 terpenes, 31 flavonoids, 22 organic acids, 18 peptides, 9 coumarins, 3 steroids, 3 anthraquinones and 3 aldehydes were identified or tentatively characterized, among which 59 components were confirmed by comparison with the standard references. Meanwhile, the accurate mass measurements of the identified components were all with ±5 ppm error. Therefore, this work provided not only reliable data supports for the comprehensive analysis of the chemical constituents in RA, but also provided an efficient data acquisition and mining strategy to profile the chemical constituents for other traditional Chinese medicine complex system.

Aster tataricus  /  UHPLC-Q-TOF-MS/MS  /  data acquisition and mining  /  comprehensive components analysis
Yi-jun CHEN, Hao WU, Zi-yi WEI, Lian-ming CHEN, Jiao-jiao DONG, Jie LIU, Zhi-xin JIA, Hong-bin XIAO. Identification of chemical constituents in Aster tataricus by UHPLC-Q-TOF-MS[J]. Acta Pharmaceutica Sinica, 2019 , 54 (9) : 1645 -1654 . DOI: 10.16438/j.0513-4870.2019-0214
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Article Info
doi: 10.16438/j.0513-4870.2019-0214
  • Receive Date：2019-03-28
  • Online Date：2026-01-26
  • Published：2019-09-12
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History
  • Received：2019-03-28
  • Revised：2019-04-30
Funding
Affiliations
    1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China
    2. Beijing Key Laboratory of Syndrome Prescription Basic Research, Beijing University of Chinese Medicine, Beijing 100029, China
    3. Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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